CaltechAUTHORS
  A Caltech Library Service

Relation between speckle decorrelation and optical phase conjugation (OPC)-based turbidity suppression through dynamic scattering media: a study on in vivo mouse skin

Jang, Mooseok and Ruan, Haowen and Vellekoop, Ivo M. and Judkewitz, Benjamin and Chung, Euiheon and Yang, Changhuei (2015) Relation between speckle decorrelation and optical phase conjugation (OPC)-based turbidity suppression through dynamic scattering media: a study on in vivo mouse skin. Biomedical Optics Express, 6 (1). pp. 72-85. ISSN 2156-7085. PMCID PMC4317115. https://resolver.caltech.edu/CaltechAUTHORS:20150206-114208650

[img] PDF - Published Version
See Usage Policy.

4Mb

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20150206-114208650

Abstract

Light scattering in biological tissue significantly limits the accessible depth for localized optical interrogation and deep-tissue optical imaging. This challenge can be overcome by exploiting the time-reversal property of optical phase conjugation (OPC) to reverse multiple scattering events or suppress turbidity. However, in living tissue, scatterers are highly movable and the movement can disrupt time-reversal symmetry when there is a latency in the OPC playback. In this paper, we show that the motion-induced degradation of the OPC turbidity-suppression effect through a dynamic scattering medium shares the same decorrelation time constant as that determined from speckle intensity autocorrelation – a popular conventional measure of scatterer movement. We investigated this decorrelation characteristic time through a 1.5-mm-thick dorsal skin flap of a living mouse and found that it ranges from 50 ms to 2.5 s depending on the level of immobilization. This study provides information on relevant time scales for applying OPC to living tissues.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1364/BOE.6.000072DOIArticle
http://www.opticsinfobase.org/boe/abstract.cfm?uri=boe-6-1-72PublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317115/PubMed CentralArticle
ORCID:
AuthorORCID
Yang, Changhuei0000-0001-8791-0354
Additional Information:© 2014 Optical Society of America. Received 11 Aug 2014; revised 19 Nov 2014; accepted 3 Dec 2014; published 10 Dec 2014. This work is supported by NIH 1DP2OD007307-01 and a GIST-Caltech Research Collaboration grant and grants from the Institute of Medical System Engineering at GIST. Benjamin Judkewitz is the recipient of a Sir Henry Wellcome Fellowship from the Wellcome Trust. The authors thank Mr. Yeonsu Jung for help with in vivo experiments and theoretical development.
Funders:
Funding AgencyGrant Number
NIH1DP2OD007307-01
GIST-Caltech Research CollaborationUNSPECIFIED
GIST Institute of Medical System EngineeringUNSPECIFIED
Wellcome TrustUNSPECIFIED
Sir Henry Wellcome FellowshipUNSPECIFIED
Issue or Number:1
Classification Code:OCIS codes: (070.5040); (170.7050); (190.5040); (090.1995); (110.1080)
PubMed Central ID:PMC4317115
Record Number:CaltechAUTHORS:20150206-114208650
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150206-114208650
Official Citation:Relation between speckle decorrelation and optical phase conjugation (OPC)-based turbidity suppression through dynamic scattering media: a study on in vivo mouse skin Mooseok Jang, Haowen Ruan, Ivo M. Vellekoop, Benjamin Judkewitz, Euiheon Chung, and Changhuei Yang Biomedical Optics Express, Vol. 6, Issue 1, pp. 72-85 (2015) http://dx.doi.org/10.1364/BOE.6.000072
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:54484
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:06 Feb 2015 21:16
Last Modified:09 Mar 2020 13:19

Repository Staff Only: item control page