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Heme-Heme Orientation and Electron Transfer Kinetic Behavior of Multisite Oxidation-Reduction Enzymes

Makinen, Marvin W. and Schichman, Steven A. and Hill, Susan C. and Gray, Harry B. (1983) Heme-Heme Orientation and Electron Transfer Kinetic Behavior of Multisite Oxidation-Reduction Enzymes. Science, 222 (4626). pp. 929-931. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20150209-090647293

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Abstract

Analysis of the polarized single-crystal absorption spectra of cytochrome cd1 of Pseudomonas aeruginosa shows that the heme c and heme d_1 groups in each subunit are oriented perpendicularly to each other in both oxidized and reduced forms of the enzyme. These results, together with those of previous kinetic studies, indicate that a perpendicular heme-heme orientation may be an important factor in specifying kinetically slow steps in a sequential series of electron transfer reactions.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.6415814 DOIArticle
http://www.sciencemag.org/content/222/4626/929.abstractPublisherArticle
http://www.jstor.org/stable/1691778JSTORArticle
ORCID:
AuthorORCID
Gray, Harry B.0000-0002-7937-7876
Additional Information:© 1983 American Association for the Advancement of Science. 13 June 1983; accepted 21 September 1983. We thank Dr. T. Takano for providing crystals of cytochrome cd_1. Supported by NSF grant PCM 77-13479 (M.W.M.), American Heart Association grant-in-aid 77378 (M.W.M.), NSF grant CHE 82-18502 (H.B.G.), and NIH training grant 1-T32-HD-07009 (S.A.S.). This is contribution No. 6774 from the Arthur Amos Noyes Laboratory.
Funders:
Funding AgencyGrant Number
NSFPCM 77-13479
American Heart Association77378
NSFCHE 82-18502
NIH1-T32-HD-07009
Other Numbering System:
Other Numbering System NameOther Numbering System ID
Caltech Arthur Amos Noyes Laboratory6774
Issue or Number:4626
Record Number:CaltechAUTHORS:20150209-090647293
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150209-090647293
Official Citation:Heme-heme orientation and electron transfer kinetic behavior of multisite oxidation-reduction enzymes MW Makinen, SA Schichman, SC Hill, and HB Gray Science 25 November 1983: 222 (4626), 929-931. [DOI:10.1126/science.6415814]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:54522
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:09 Feb 2015 21:30
Last Modified:22 Nov 2019 09:58

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