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Developmentally Controlled Expression of Immunoglobulin V_H genes

Perlmutter, Roger M. and Kearny, John F. and Chang, Sandra P. and Hood, Leroy E. (1985) Developmentally Controlled Expression of Immunoglobulin V_H genes. Science, 227 (4694). pp. 1597-1601. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20150209-094212744

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Abstract

Although antibody diversity arises mainly from apparently random combinatorial and somatic mutational mechanisms acting upon a limited number of germline antibody genes, the antibody repertoire develops in an ordered fashion during mammalian ontogeny. A series of early pre-B and B-lymphocyte cell lines were examined to determine whether an ordered rearrangement of gene families of the variable region of immunoglobulin heavy chains (V_H) may be the basis for the programmed development of the antibody response. The results indicated that the V_H repertoire of fetal B-lineage cells is largely restricted to the V_H 7183 gene family and that subsequent recruitment of additional V_H gene families occurs during neonatal development. These results have important implications in understanding the ontogeny of immune function.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.3975629DOIArticle
http://www.sciencemag.org/content/227/4694/1597.abstractPublisherArticle
http://www.jstor.org/stable/1694902 JSTORArticle
Additional Information:© 1985 American Association for the Advancement of Science. 3 August 1984; accepted 4 January 1985. Supported by a New Investigator Research Award AI18088 (R.M.P.) and a Procter and Gamble postdoctoral fellowship (S.P.C.). We thank M. Shapiro and P. Brodeur for the V_H Q52 probe; J. Klotz, M. Kronenberg, and P. Gearhart for valuable discussions; and C. Katz for preparing the manuscript.
Funders:
Funding AgencyGrant Number
NIHAI18088
Procter and GambleUNSPECIFIED
Issue or Number:4694
Record Number:CaltechAUTHORS:20150209-094212744
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150209-094212744
Official Citation:Developmentally controlled expression of immunoglobulin VH genes RM Perlmutter, JF Kearney, SP Chang, and LE Hood Science 29 March 1985: 227 (4694), 1597-1601. [DOI:10.1126/science.3975629]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:54525
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:09 Feb 2015 21:25
Last Modified:03 Oct 2019 07:58

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