Hurley, James B. and Simon, Melvin I. and Teplow, David B. and Robishaw, Janet D. and Gilman, Alfred G. (1984) Homologies between Signal Transducing G Proteins and ras Gene Products. Science, 226 (4676). pp. 860-862. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20150209-101315516
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Abstract
The guanosine triphosphate-binding proteins (G proteins) found in a variety of tissues transduce signals generated by ligand binding to cell surface receptors into changes in intracellular metabolism. Amino acid sequences of peptides prepared by partial proteolysis of the alpha subunit of a bovine brain G protein and the alpha subunit of rod outer-segment transducin were determined. The two proteins show regions of sequence identity as well as regions of diversity. A portion of the amino-terminal peptide sequence of each protein is highly homologous with the corresponding region in the ras protein (a protooncogene product). These similarities suggest that G proteins and ras proteins may have analogous functions.
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| Additional Information: | © 1984 American Association for the Advancement of Science. 20 September 1984; Accepted 16 October 1984. We thank Michael Lochrie for helpful discussions and Rosemary Hopkins for technical assistance. Supported by NIH grant NS 18153 (A.G.G.), American Cancer Society grant BC 240 (A.G,G.), NIH fellowship GM 09731-02 (J.D.R.), and NSF grant PCM 8411039 (M.I.S.). | ||||||||||||
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| Issue or Number: | 4676 | ||||||||||||
| Record Number: | CaltechAUTHORS:20150209-101315516 | ||||||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20150209-101315516 | ||||||||||||
| Official Citation: | Homologies between signal transducing G proteins and ras gene products JB Hurley, MI Simon, DB Teplow, JD Robishaw, and AG Gilman Science 16 November 1984: 226 (4676), 860-862. [DOI:10.1126/science.6436980] | ||||||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||
| ID Code: | 54534 | ||||||||||||
| Collection: | CaltechAUTHORS | ||||||||||||
| Deposited By: | Ruth Sustaita | ||||||||||||
| Deposited On: | 09 Feb 2015 20:24 | ||||||||||||
| Last Modified: | 03 Oct 2019 07:58 |
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