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Homologies between Signal Transducing G Proteins and ras Gene Products

Hurley, James B. and Simon, Melvin I. and Teplow, David B. and Robishaw, Janet D. and Gilman, Alfred G. (1984) Homologies between Signal Transducing G Proteins and ras Gene Products. Science, 226 (4676). pp. 860-862. ISSN 0036-8075. doi:10.1126/science.6436980.

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The guanosine triphosphate-binding proteins (G proteins) found in a variety of tissues transduce signals generated by ligand binding to cell surface receptors into changes in intracellular metabolism. Amino acid sequences of peptides prepared by partial proteolysis of the alpha subunit of a bovine brain G protein and the alpha subunit of rod outer-segment transducin were determined. The two proteins show regions of sequence identity as well as regions of diversity. A portion of the amino-terminal peptide sequence of each protein is highly homologous with the corresponding region in the ras protein (a protooncogene product). These similarities suggest that G proteins and ras proteins may have analogous functions.

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Additional Information:© 1984 American Association for the Advancement of Science. 20 September 1984; Accepted 16 October 1984. We thank Michael Lochrie for helpful discussions and Rosemary Hopkins for technical assistance. Supported by NIH grant NS 18153 (A.G.G.), American Cancer Society grant BC 240 (A.G,G.), NIH fellowship GM 09731-02 (J.D.R.), and NSF grant PCM 8411039 (M.I.S.).
Funding AgencyGrant Number
NIHNS 18153
American Cancer SocietyBC 240
NIH FellowshipGM 09731-02
NSFPCM 8411039
Issue or Number:4676
Record Number:CaltechAUTHORS:20150209-101315516
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Official Citation:Homologies between signal transducing G proteins and ras gene products JB Hurley, MI Simon, DB Teplow, JD Robishaw, and AG Gilman Science 16 November 1984: 226 (4676), 860-862. [DOI:10.1126/science.6436980]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:54534
Deposited By: Ruth Sustaita
Deposited On:09 Feb 2015 20:24
Last Modified:10 Nov 2021 20:34

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