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An Isomorphous Replacement Method for Phasing Twinned Structures

Yeates, T. O. and Rees, D. C. (1987) An Isomorphous Replacement Method for Phasing Twinned Structures. Acta Crystallographica. Section A, Foundations of Crystallography, 43 (1). pp. 30-36. ISSN 0108-7673. doi:10.1107/S0108767387099951.

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A linear least-squares formulation of the method of isomorphous replacement is presented. With data from untwinned crystals, this approach is shown to be equivalent to the phasing representation developed by Hendrickson & Lattman [Acta Cryst. (1970). B26, 136-143]. A general method for calculating the most probable phase is described and applied to the higher- dimensional problem of phase determination for twinned structures. A method for calculating the best phase with intensity data from twinned crystals is also presented. The dependences of these phasing procedures on the number of derivatives and accuracy of the data sets are evaluated in test calculations.

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Rees, D. C.0000-0003-4073-1185
Additional Information:© 1987 International Union of Crystallography. Received 5 August 1985; accepted 12 May 1986. This work was supported in part by USPHS grant GM31875 and USPHS NRS award GM07185 to TOY.
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U.S. Public Health ServiceGM07185
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Record Number:CaltechAUTHORS:20150209-104210949
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ID Code:54551
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Deposited On:09 Feb 2015 21:53
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