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Automated Chemical Synthesis of a Protein Growth Factor for Hemopoietic Cells, Interleukin-3

Clark-Lewis, Ian and Aebersold, Ruedi and Ziltener, Herman and Schrader, John W. and Hood, Leroy E. and Kent, Stephen B. H. (1986) Automated Chemical Synthesis of a Protein Growth Factor for Hemopoietic Cells, Interleukin-3. Science, 231 (4734). pp. 134-139. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20150209-113416478

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Abstract

Interleukin-3 (IL-3), a protein of 140 amino acids, was chemically synthesized by means of an automated peptide synthesizer and was shown to have the biological activities attributed to native IL-3. Assays of synthetic analogues established that an amino terminal fragment has detectable IL-3 activity, but that the stable tertiary structure of the complete molecule was required for full activity. The results demonstrate that automated peptide synthesis can be applied to the study of the structure and function of proteins.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.3079915DOIArticle
http://www.sciencemag.org/content/231/4734/134.abstractPublisherArticle
http://www.jstor.org/stable/1696746 JSTORArticle
Additional Information:© 1986 American Association for the Advancement of Science. 7 October 1985; accepted 2 December 1985. Supported by research grants from the National Institutes of Health, the Monsanto Company, and Upjohn Pharmaceuticals. Additional support was obtained from the National Health and Medical Research Council, Canberra, Australia; NIH grant R01-CA38684-0l (J.W.S.); a C.]. Martin Traveling Fellowship from the National Health and Medical Research Council, Canberra, Australia (I.C.L.), an EMBO long-term fellowship (R.A.) and fellowships from the Swiss National Foundation (R.A. and H.Z.). We thank C. Davis and J. Kim for expert technical assistance.
Funders:
Funding AgencyGrant Number
NIHUNSPECIFIED
Monsanto CompanyUNSPECIFIED
Upjohn PharmaceuticalsUNSPECIFIED
National Health and Medical Research Council (Australia)UNSPECIFIED
NIHR01-CA38684-01
EMBOUNSPECIFIED
Swiss National FoundationUNSPECIFIED
Issue or Number:4734
Record Number:CaltechAUTHORS:20150209-113416478
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150209-113416478
Official Citation:Automated chemical synthesis of a protein growth factor for hemopoietic cells, interleukin-3 I Clark-Lewis, R Aebersold, H Ziltener, JW Schrader, LE Hood, and SB Kent Science 10 January 1986: 231 (4734), 134-139. [DOI:10.1126/science.3079915]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:54556
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:09 Feb 2015 20:10
Last Modified:03 Oct 2019 07:58

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