Molecular Evolution Activities

This is a comprehensive bibliography (under construction) of primary and secondary sources on the neutral theory of molecular evolution. It currently covers the period 1973-2001.

Author :

Colgan, D. J.

Year :


Title :

Interspecific Isozymic Substitution Is Not Random

Journal :


Volume :


Pages :


Date :


Short Title :

Interspecific Isozymic Substitution Is Not Random

Alternate Journal :


Custom 2 :


Abstract :

The validity of the neutral theory of molecular evolution, which holds that almost all allelic substitution during evolution has been due to random genetic drift, is a pivotal question in evolutionary biology. Here it is shown that the theory predicts a 1:1 ratio among isozymes in a species between those which are faster (i.e. have greater anodal mobilities) and those which are slower (i.e. have lesser anodal mobilities) than their homologues in a related species. In fact, observed patterns of isozymic variation display deviations from such a ratio. Significant departures from expected values were found for reptiles, fish and insects. A near significant result was seen for amphibia. The overall deviations are highly significant. The results strongly suggest that a substantial fraction of allozymic substitution has been due to positive Darwinian selection.

Notes :

Times Cited: 2 2 JG280 HEREDITY
 -- contributed by John Beatty, March 29, 2002