Molecular Evolution Activities
 

This is a comprehensive bibliography (under construction) of primary and secondary sources on the neutral theory of molecular evolution. It currently covers the period 1973-2001.

Author :

Gauldie, R. W.

Year :

1996

Title :

Testing neutral theorists: Revisiting heterozygosities at the phosphoglucomutase locus and glucose phosphate isomerase locus

Journal :

Comparative Biochemistry and Physiology B-Biochemistry & Molecular Biology

Volume :

115

Issue :

1

Pages :

47-56

Date :

Sep

Short Title :

Testing neutral theorists: Revisiting heterozygosities at the phosphoglucomutase locus and glucose p

Alternate Journal :

Comp. Biochem. Physiol. B-Biochem. Mol. Biol.

Custom 2 :

ISI:A1996VK16000007

Abstract :

A previous examination (6) of the distribution of frequencies of protein polymorphisms at the phosphoglucomutase and glucose phosphate isomerase loci showed a statistical bias against both loci being simultaneously polymorphic. A rebuttal of these findings based on a neutral theory approach to analysis has been published that argues against such a bias. The neutral theory approach is disputed on the grounds that 1) a fundamentally different data set was used and 2) that the data was skewed by the use of inappropriate transforms: Upgrading the original data with new observations confirms the original observation of a statistical bias against both loci being simultaneously polymorphic. A model based on different chemistries associated with different polymorphism can explain the observed distribution of PGM and GPI heterozygosities.

Notes :

Times Cited: 0 VK160 COMP BIOCHEM PHYSIOL PT B
 -- contributed by John Beatty, March 29, 2002