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| This is a comprehensive bibliography (under construction) of primary and secondary sources on the neutral theory of molecular evolution. It currently covers the period 1973-2001. |
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Author :
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Gillespie, J. H.
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Year :
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1995
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Title :
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On Ohta Hypothesis - Most Amino-Acid Substitutions Are Deleterious
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Journal :
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Journal of Molecular Evolution
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Volume :
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40
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Issue :
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1
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Pages :
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64-69
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Date :
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Jan
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Short Title :
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On Ohta Hypothesis - Most Amino-Acid Substitutions Are Deleterious
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Alternate Journal :
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J. Mol. Evol.
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Custom 2 :
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ISI:A1995PZ28900008
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Abstract :
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Ohta's hypothesis that most amino acid substitutions are deleterious grew out of a class of population-genetics models called shift models. Recently, shift models have been shown to be biologically unreasonable and have been replaced by a more plausible house-of-cards model. In this paper, the simplest form of the house-of-cards models is shown to be incompatible with most of the major features of protein evolution. Moreover, this model is shown to not be a model of exclusively deleterious-allele evolution, but rather to be a model with an equal mix of deleterious and advantageous substitutions.
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Notes :
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Times Cited: 20
PZ289
J MOL EVOL
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| | -- contributed by John Beatty, March 29, 2002 |
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