Author :
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Ford, M. J.;Thornton, P. J.;Park, L. K.
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Year :
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1999
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Title :
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Natural selection promotes divergence of transferrin among salmonid species
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Journal :
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Molecular Ecology
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Volume :
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8
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Issue :
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6
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Pages :
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1055-1061
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Date :
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Jun
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Short Title :
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Natural selection promotes divergence of transferrin among salmonid species
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Alternate Journal :
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Mol. Ecol.
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Custom 2 :
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ISI:000081624800014
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Abstract :
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Transferrin is an iron-binding protein that plays an important role in iron metabolism and resistance to bacterial infection in a variety of organisms. A comparison of transferrin coding sequences from four salmonid species shows that the rate of evolution at nonsynonymous sites is significantly higher than the rate at synonymous sites, suggesting that positive natural selection for new alleles has played an important role in the evolution of transferrin in some salmon species. We hypothesize that the selective agent driving rapid divergence is interactions between host transferrin and the iron-scavenging proteins of pathogenic bacteria.
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Notes :
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Times Cited: 3
219UE
MOL ECOL
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| -- contributed by John Beatty, March 29, 2002 |
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