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| This is a comprehensive bibliography (under construction) of primary and secondary sources on the neutral theory of molecular evolution. It currently covers the period 1973-2001. |
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Author :
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Jukes, T. H.
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Year :
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1978
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Title :
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Neutral changes during divergent evolution of hemoglobins
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Journal :
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Journal of Molecular Evolution
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Volume :
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11
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Issue :
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3
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Pages :
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267-9
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Short Title :
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Neutral changes during divergent evolution of hemoglobins
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Custom 3 :
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79007516
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Abstract :
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A comparison of the mRNAs for rabbit and human beta-hemoglobins shows that synonymous changes in codons have accumulated three times as rapidly as nucleotide replacements that produced changes in amino acids. This agrees with predictions based on the so-called 'neutral theory'. In addition, seven codon changes that appear to be single-base changes (according to 'maximum parsimony') are actually two-base changes. This indicates that the construction of "primordial sequences" is of limited signficance when based on inferences that assume minimum base changes for amino acid replacements.
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| | -- contributed by John Beatty, March 29, 2002 |
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