Molecular Evolution Activities
 

This is a comprehensive bibliography (under construction) of primary and secondary sources on the neutral theory of molecular evolution. It currently covers the period 1973-2001.

Author :

Hudson, R. R.;Kreitman, M.;Aguade, M.

Year :

1987

Title :

A test of neutral molecular evolution based on nucleotide data

Journal :

Genetics

Volume :

116

Issue :

1

Pages :

153-9

Short Title :

A test of neutral molecular evolution based on nucleotide data

Custom 3 :

87248034

Abstract :

The neutral theory of molecular evolution predicts that regions of the genome that evolve at high rates, as revealed by interspecific DNA sequence comparisons, will also exhibit high levels of polymorphism within species. We present here a conservative statistical test of this prediction based on a constant-rate neutral model. The test requires data from an interspecific comparison of at least two regions of the genome and data on levels of intraspecific polymorphism in the same regions from at least one species. The model is rejected for data from the region encompassing the Adh locus and the 5' flanking sequence of Drosophila melanogaster and Drosophila sechellia. The data depart from the model in a direction that is consistent with the presence of balanced polymorphism in the coding region.
 -- contributed by John Beatty, March 29, 2002