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This is a comprehensive bibliography (under construction) of primary and secondary sources on the neutral theory of molecular evolution. It currently covers the period 1973-2001. |
Author :
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Ina, Y.;Mizokami, M.;Ohba, K.;Gojobori, T.
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Year :
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1994
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Title :
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Reduction of Synonymous Substitutions in the Core Protein Gene of Hepatitis-C Virus
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Journal :
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Journal of Molecular Evolution
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Volume :
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38
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Issue :
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1
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Pages :
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50-56
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Date :
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Jan
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Short Title :
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Reduction of Synonymous Substitutions in the Core Protein Gene of Hepatitis-C Virus
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Alternate Journal :
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J. Mol. Evol.
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Custom 2 :
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ISI:A1994MN38200006
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Abstract :
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Molecular evolutionary analyses were carried out to elucidate the phylogenetic relationships, the evolutionary rate, and the divergence times of hepatitis C viruses. Using the nucleotide sequences of the viruses isolated from various locations in the world, we constructed phylogenetic trees. The trees showed that strains isolated from a single location were not necessarily clustered as a group. This suggests that the viruses may be transferred with blood on a worldwide scale. We estimated the evolutionary rates at synonymous and nonsynonymous sites for all genes in the viral genome. We then found that the rate (1.35x10(-3) per site per year) at synonymous sites for the C gene was much smaller than those for the other genes (e.g., 6.29x10(-3) per site per year for the E gene). This indicates that a special type of functional constraint an synonymous substitutions may exist in the C gene. Because we found an open reading frame (ORF) with the C gene region, the possibility exists that synonymous substitutions for the C gene are constrained by the overlapping ORF whose reading frame is different from that of the C gene. Applying the evolutionary rates to the trees, we also suggest that major groups of hepatitis C viruses diverged from their common ancestor several hundred years ago.
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Notes :
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Times Cited: 33
MN382
J MOL EVOL
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| -- contributed by John Beatty, March 29, 2002 |
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