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| This is a comprehensive bibliography (under construction) of primary and secondary sources on the neutral theory of molecular evolution. It currently covers the period 1973-2001. |
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Author :
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Karn, R. C.;Nachman, M. W.
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Year :
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1999
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Title :
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Reduced nucleotide variability at an androgen-binding protein locus (Abpa) in house mice: Evidence for positive natural selection
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Journal :
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Molecular Biology and Evolution
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Volume :
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16
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Issue :
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9
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Pages :
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1192-1197
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Date :
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Sep
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Short Title :
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Reduced nucleotide variability at an androgen-binding protein locus (Abpa) in house mice: Evidence f
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Alternate Journal :
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Mol. Biol. Evol.
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Custom 2 :
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ISI:000082431300008
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Abstract :
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Previous work has shown that the gene for the alpha subunit of androgen-binding protein, Abpa, may be involved in premating isolation between different subspecies of the house mouse, Mus musculus. We investigated patterns of DNA sequence variation at Abpa within and between species of mice to test several predictions of a model of neutral molecular evolution. Intraspecific variation among 10 Mus musculus domesticus alleles was compared with divergence between M. m. domesticus and M. caroli for Abpa and two X-linked genes, Glra2 and Amg. No variation was observed at Abpa within M. in. domesticus. The ratio of polymorphism to divergence was significantly lower at Abpa than at Glra2 and Amg, despite the fact that all three genes experience similar rates of recombination. Interspecific comparisons among M. rn. domesticus, Mus musculus musculus, Mus musculus castaneus, Mus spretus, Mus spicilegus, and Mus caroli revealed that the ratio of nonsynonymous substitutions to synonymous substitutions on a per-site basis (K-a/K-s) was generally greater than one. The combined observations of no variation at Abpa within M. m. domesticus and uniformly high K- a/K-s values between species suggest that positive directional selection has acted recently at this locus.
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Notes :
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Times Cited: 7
233MU
MOL BIOL EVOL
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| | -- contributed by John Beatty, March 29, 2002 |
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