Molecular Evolution Activities
 

This is a comprehensive bibliography (under construction) of primary and secondary sources on the neutral theory of molecular evolution. It currently covers the period 1973-2001.

Author :

Lewontin, R. C.;Hartl, D. L.

Year :

1991

Title :

Population-Genetics in Forensic DNA Typing

Journal :

Science

Volume :

254

Issue :

5039

Pages :

1745-1750

Date :

Dec 20

Short Title :

Population-Genetics in Forensic DNA Typing

Alternate Journal :

Science

Custom 2 :

ISI:A1991GW31600031

Abstract :

Variable number of tandem repeat (VNTR) sequences are used to link defendants with crimes by matching DNA patterns. The probative value of a match is often calculated by multiplying together the estimated frequencies with which each particular VNTR pattern occurs in a reference database. However, this method is liable to potential serious errors because ethnic subgroups within major racial categories exhibit genetic differences that are maintained by endogamy. The multiplication procedure currently in use can be made scientifically valid only by extensive sampling of VNTR frequency distributions m a variety of ethnic groups, similar to the ethnic studies of various blood groups done m the past. Alternative approaches for dealing with subpopulation heterogeneity are discussed.

Notes :

Times Cited: 162 GW316 SCIENCE
 -- contributed by John Beatty, March 29, 2002