Molecular Evolution Activities
 

This is a comprehensive bibliography (under construction) of primary and secondary sources on the neutral theory of molecular evolution. It currently covers the period 1973-2001.

Author :

Ohta, T.

Year :

1992

Title :

Theoretical-Study of near Neutrality .2. Effect of Subdivided Population-Structure with Local Extinction and Recolonization

Journal :

Genetics

Volume :

130

Issue :

4

Pages :

917-923

Date :

Apr

Short Title :

Theoretical-Study of near Neutrality .2. Effect of Subdivided Population-Structure with Local Extinc

Alternate Journal :

Genetics

Custom 2 :

ISI:A1992HL49000020

Abstract :

There are several unsolved problems concerning the model of nearly neutral mutations. One is the interaction of subdivided population structure and weak selection that spatially fluctuates. The model of nearly neutral mutations whose selection coefficient spatially fluctuates has been studied by adopting the island model with periodic extinction- recolonization. Both the number of colonies and the migration rate play significant roles in determining mutants' behavior, and selection is ineffective when the extinction-recolonization is frequent with low migration rate. In summary, the number of mutant substitutions decreases and the polymorphism increases by increasing the total population size, and/or decreasing the extinction-recolonization rate. However, by increasing the total size of the population, the mutant substitution rate does not become as low when compared with that in panmictic populations, because of the extinction-recolonization, especially when the migration rate is limited. It is also found that the model satisfactorily explains the contrasting patterns of molecular polymorphisms observed in sibling species of Drosophila, including heterozygosity, proportion of polymorphism and fixation index.

Notes :

Times Cited: 7 HL490 GENETICS
 -- contributed by John Beatty, March 29, 2002