Molecular Evolution Activities

This is a comprehensive bibliography (under construction) of primary and secondary sources on the neutral theory of molecular evolution. It currently covers the period 1973-2001.

Author :

Ohta, T.

Year :


Title :

Interaction of Selection and Drift in Molecular Evolution

Journal :

Japanese Journal of Genetics

Volume :


Issue :


Pages :


Date :


Short Title :

Interaction of Selection and Drift in Molecular Evolution

Alternate Journal :

Jpn. J. Genet.

Custom 2 :


Abstract :

The nearly neutral theory proposes that interaction of selection and drift is important in molecular evolution. The theory predicts that evolutionary rate is negatively correlated with the species population size, for those genes whose function has been fixed long time ago. The prediction is tested through analysis of sequence data of 17 mammalian genes by estimating divergence among genes separately for synonymous substitutions and nonsynonymous substitutions. Star phylogenies composed of rodentia, artiodactyla and primates are examined. The generation-time effect is found to be more conspicuous for synonymous substitutions than for nonsynonymous substitutions. This result supports the nearly neutral theory.

Notes :

Times Cited: 1 NL379 JPN J GENET
 -- contributed by John Beatty, March 29, 2002