Kothakota, Srinivas and Dougherty, Michael J. and Fournier, Maurille J. and Mason, Thomas L. and Yoshikawa, Eiichiro and Tirrell, David A. (1995) Templated biological synthesis of polymers of abiological monomers. Macromolecular Symposia, 98 (1). pp. 573-583. ISSN 1022-1360. doi:10.1002/masy.19950980149. https://resolver.caltech.edu/CaltechAUTHORS:20150303-163920828
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Abstract
A general method for the in vivo incorporation of amino acid analogues into artificial proteins is described. The method involves the construction of an artificial gene encoding the sequence of interest (with the corresponding natural amino acid encoded in place of the analogue), transformation of a bacterial host strain that cannot synthesize the natural amino acid, and induction of protein synthesis in a host culture enriched in the analogue. Results are described for the amino acid analogues selenomethionine, p-fluorophenylalanine, trifluoroleucine and 3-thienylalanine.
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| Additional Information: | Copyright © 1995 Hüthig & Wepf Verlag. Issue published online: 4 MAR 2011. Article first published online: 4 MAR 2011. The work described herein has been supported by grants from the Polymers and Genetics Programs of the National Science Foundation, the U.S. Army Research Office, and the Materials Research Science and Engineering Center at the University of Massachusetts. | |||||||||
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| Issue or Number: | 1 | |||||||||
| DOI: | 10.1002/masy.19950980149 | |||||||||
| Record Number: | CaltechAUTHORS:20150303-163920828 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20150303-163920828 | |||||||||
| Official Citation: | Kothakota, S., Dougherty, M. J., Fournier, M. J., Mason, T. L., Yoshikawa, E. and Tirrell, D. A. (1995), Templated biological synthesis of polymers of abiological monomers. Macromol. Symp., 98: 573–583. doi: 10.1002/masy.19950980149 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 54561 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Anne Hormann | |||||||||
| Deposited On: | 04 Mar 2015 00:53 | |||||||||
| Last Modified: | 10 Nov 2021 20:35 |
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