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Templated biological synthesis of polymers of abiological monomers

Kothakota, Srinivas and Dougherty, Michael J. and Fournier, Maurille J. and Mason, Thomas L. and Yoshikawa, Eiichiro and Tirrell, David A. (1995) Templated biological synthesis of polymers of abiological monomers. Macromolecular Symposia, 98 (1). pp. 573-583. ISSN 1022-1360. doi:10.1002/masy.19950980149.

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A general method for the in vivo incorporation of amino acid analogues into artificial proteins is described. The method involves the construction of an artificial gene encoding the sequence of interest (with the corresponding natural amino acid encoded in place of the analogue), transformation of a bacterial host strain that cannot synthesize the natural amino acid, and induction of protein synthesis in a host culture enriched in the analogue. Results are described for the amino acid analogues selenomethionine, p-fluorophenylalanine, trifluoroleucine and 3-thienylalanine.

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Tirrell, David A.0000-0003-3175-4596
Additional Information:Copyright © 1995 Hüthig & Wepf Verlag. Issue published online: 4 MAR 2011. Article first published online: 4 MAR 2011. The work described herein has been supported by grants from the Polymers and Genetics Programs of the National Science Foundation, the U.S. Army Research Office, and the Materials Research Science and Engineering Center at the University of Massachusetts.
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National Science Foundation Polymers and Genetics ProgramsUNSPECIFIED
U.S. Army Research OfficeUNSPECIFIED
Materials Research Science and Engineering Center (MRSEC)UNSPECIFIED
Issue or Number:1
Record Number:CaltechAUTHORS:20150303-163920828
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Official Citation:Kothakota, S., Dougherty, M. J., Fournier, M. J., Mason, T. L., Yoshikawa, E. and Tirrell, D. A. (1995), Templated biological synthesis of polymers of abiological monomers. Macromol. Symp., 98: 573–583. doi: 10.1002/masy.19950980149
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:54561
Deposited By: Anne Hormann
Deposited On:04 Mar 2015 00:53
Last Modified:10 Nov 2021 20:35

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