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Interactions of synthetic polymers with cell membranes and model membrane systems, 9. Reversal of Mg^(2+) Induced Structural Changes in Dipalmitoylphosphatidylglycerol Bilayers by Adsorbed Polyethyleneimines

Takigawa, Doreen Y. and Tirrell, David A. (1985) Interactions of synthetic polymers with cell membranes and model membrane systems, 9. Reversal of Mg^(2+) Induced Structural Changes in Dipalmitoylphosphatidylglycerol Bilayers by Adsorbed Polyethyleneimines. Makromolecular Chemistry, Rapid Communications, 6 (10). pp. 653-657. ISSN 0173-2803. http://resolver.caltech.edu/CaltechAUTHORS:20150209-162227223

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Abstract

One can imagine a number of different ways in which synthetic polymers might modify the structural and functional properties of bilayer membranes. Our own experiments on polymer-lipid mixtures have demonstrated several of these. Treatment of aqueous phosphatidylcholine suspensions with poly(2-ethylacrylic acid) was shown by Tirrell, Takigawa and Seki to provide a method of preparation of environmentally sensitive vesicles which release their contents in a controlled manner in response to small changes in local pH. The most likely mechanism by which the polymer may effect vesicle disruption is that shown in Scheme 1: a pH-dependent conformational transition in poly(2-ethylacrylic acid) produces a globular, hydrophobic form of the polymer which solubilizes the lipid in the form of mixed micelles. More recently, we have described the observation of an unusual interdigitated gel phase in phosphatidylglycerol bilayers treated with ionene-6, (Scheme 2). Interdigitation results in a near-doubling of the lateral area of the bilayer, as the bilayer thickness is reduced to little more than half its normal value. We are currently exploring the consequences of this structural change in terms of bilayer stability and permeability.


Item Type:Article
ORCID:
AuthorORCID
Tirrell, David A.0000-0003-3175-4596
Additional Information:© 1985 Huethig und Wepf. (Date of receipt: March 25, 1985) This work was supported by a grant from the 3M Company, St. Paul, MN. Support of our research programs by the Alfred P. Sloan Foundation (Research Fellowship to D.A.T.) and by a Presidential Young Investigator Award of the National Science Foundation (to D.A.T.) is also gratefully acknowledged.
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3MUNSPECIFIED
Alfred P. Sloan FoundationUNSPECIFIED
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ID Code:54609
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Deposited By: Anne Hormann
Deposited On:12 Feb 2015 01:11
Last Modified:12 Feb 2015 01:11

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