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pH-Dependent Structural Modification of Dipalmitoylphosphatidylcholine Vesicle Membranes by a Degradable Poly(carboxylic acid) of Pharmacological Importance

Seki, Kenji and Tirrell, David A. and Braud, Christian and Vert, Michel (1984) pH-Dependent Structural Modification of Dipalmitoylphosphatidylcholine Vesicle Membranes by a Degradable Poly(carboxylic acid) of Pharmacological Importance. Makromolecular Chemistry, Rapid Communications, 5 (4). pp. 187-190. ISSN 0173-2803. https://resolver.caltech.edu/CaltechAUTHORS:20150209-163507967

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Abstract

The real and potential applications of phospholipid and surfactant vesicles in areas such as drug delivery, solar energy conversion, and chemical reactivity control have been discussed by Fendler. Additional applications may be foreseen for vesicles which can be made to respond to environmental stimuli such as heat, light, or specific chemical substances. One might imagine, for example, the use of such sensitized vesicles for selective release of drugs in targets of local hyperthermia) or low ambient pH). We have recently demonstrated that multilamellar vesicles of dipalmitoylphosphatidylcholine (DPPC) are rendered sensitive to pH in the presence of synthetic poly(carboxylic acid)s related to poly(acrylic acid). In biomedical applications, however, the non-degradability of these poly(acrylic acid) derivatives may be a serious limitation. In this paper, we show that a similar pH-dependent modification of DPPC vesicle structure may be effected by poly(P-malic acid) (PMLA 100), a degradable poly(carboxylic acid). PMLA 100 has been recently introduced to tailor-made macromolecular prodrugs and microemulsion-like systems for solubilization of hydrophobic drugs in aqueous media).


Item Type:Article
ORCID:
AuthorORCID
Tirrell, David A.0000-0003-3175-4596
Additional Information:© 1984 Huethig und Wepf. (Date of receipt: November 17, 1983) This work was supported by an Alfred P. Sloan Research Fellowship to D. A. Tirrell, and by a leave of absence from Idemitsu Kosan Co., Ltd., to K. Seki. Purchase of the calorimeter was assisted by a grant from the National Science Foundation (CHE-79-11206). Contributions to this work by Prof. Allan Hoffman are greatly appreciated by the authors.
Funders:
Funding AgencyGrant Number
Alfred P. Sloan FoundationUNSPECIFIED
NSFCHE-79-11206
Issue or Number:4
Record Number:CaltechAUTHORS:20150209-163507967
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150209-163507967
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:54611
Collection:CaltechAUTHORS
Deposited By: Anne Hormann
Deposited On:10 Feb 2015 20:24
Last Modified:03 Oct 2019 07:59

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