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Interaction of Synthetic Polymers with Cell Membranes and Model Membrane Systems IV. Pyran Copolymer

Marwaha, Lalat K. and Tirrell, David A. (1982) Interaction of Synthetic Polymers with Cell Membranes and Model Membrane Systems IV. Pyran Copolymer. In: Biological Activities of Polymers. ACS Symposium Series. No.186. American Chemical Society , Washington, DC, pp. 163-175. ISBN 9780841207196. http://resolver.caltech.edu/CaltechAUTHORS:20150209-164311476

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Abstract

We have investigated the interaction of pyran copolymer with erythrocyte ghosts, with intact erythrocytes and with liposomes of pure dipalmitoylphosphatidylcholine (DPPC). Particular attention was given to the importance of divalent metals (especially Ca^(2+)) in promoting the association of pyran copolymer with cell and lipid surfaces. High sensitivity differential scanning calorimetry shows: i) The perturbation of erythrocyte ghost structure by pyran copolymer is not reidily 'bashed out" by treatment with fresh buffer, ii) This perturbation is not due simply to sequestration of metal ions, iii) Pyran copolymer reverses at least partially the effects of Ca^(2+) added to erythrocyte ghosts, and iv) Pyran copolymer raises the transition temperature of DPPC liposomes in the presence of 5 mM Ca^(2+), but not in the absence of added Ca^(2+).


Item Type:Book Section
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/bk-1982-0186.ch013DOIArticle
http://pubs.acs.org/doi/abs/10.1021/bk-1982-0186.ch013PublisherArticle
ORCID:
AuthorORCID
Tirrell, David A.0000-0003-3175-4596
Additional Information:© 1982 American Chemical Society. The authors would like to thank Professors William S. Kelley and James F. Williams for use of liquid scintillation counters. This work was supported by the Health Research and Services Foundation, Pittsburgh, PA., and by the Samuel and Emma Winters Foundation. The calorimeter was purchased with the aid of National Science Foundation Grant No.. CHE-79-11206.
Funders:
Funding AgencyGrant Number
Health Research and Services FoundationUNSPECIFIED
Samuel and Emma Winters FoundationUNSPECIFIED
NSFCHE-79-11206
Record Number:CaltechAUTHORS:20150209-164311476
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20150209-164311476
Official Citation:Interaction of Synthetic Polymers with Cell Membranes and Model Membrane Systems: Pyran Copolymer LALAT K. MARWAHA and DAVID A. TIRRELL Biological Activities of Polymers. May 12, 1982, 163-175
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:54614
Collection:CaltechAUTHORS
Deposited By: Anne Hormann
Deposited On:10 Feb 2015 20:14
Last Modified:10 Feb 2015 20:14

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