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Molecular Basis for the α_1-Protease Inhibitor Deficiency

Chan, S. K. and Rees, D. C. (1975) Molecular Basis for the α_1-Protease Inhibitor Deficiency. Nature, 255 (5505). pp. 240-241. ISSN 0028-0836. http://resolver.caltech.edu/CaltechAUTHORS:20150210-100937554

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Abstract

The α_1-protease inhibitor (formerly α1-antitrypsin) is in herited by a series of autosomal codominant alleles that determine its concentration and electrophoretic mobility. Serum from individuals with severe α1-protease inhibitor deficiency usually contains an electrophoretically slow-moving α_1-protease inhibitor (type ZZ) in an amount 10–40% of that found in the normal population (type MM). This deficient state is associated with either an early-onset form of familial emphysema or familial infantile cirrhosis.


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http://dx.doi.org/10.1038/255240a0DOIArticle
http://www.nature.com/nature/journal/v255/n5505/abs/255240a0.htmlPublisherArticle
ORCID:
AuthorORCID
Rees, D. C.0000-0002-1076-1503
Additional Information:© 1975 Nature Publishing Group. Received January 27; revised April 2, 1975. This research was supported by a grant from the National Institutes of Health. We thank Drs R. Talamo and J. Pierce for performing the electrophoresis in their laboratories and for providing serum from ZZ individuals.
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Record Number:CaltechAUTHORS:20150210-100937554
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20150210-100937554
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ID Code:54661
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Deposited On:11 Feb 2015 00:00
Last Modified:21 Nov 2017 19:00

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