A Caltech Library Service

Molecular Basis for the α_1-Protease Inhibitor Deficiency

Chan, S. K. and Rees, D. C. (1975) Molecular Basis for the α_1-Protease Inhibitor Deficiency. Nature, 255 (5505). pp. 240-241. ISSN 0028-0836.

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item:


The α_1-protease inhibitor (formerly α1-antitrypsin) is in herited by a series of autosomal codominant alleles that determine its concentration and electrophoretic mobility. Serum from individuals with severe α1-protease inhibitor deficiency usually contains an electrophoretically slow-moving α_1-protease inhibitor (type ZZ) in an amount 10–40% of that found in the normal population (type MM). This deficient state is associated with either an early-onset form of familial emphysema or familial infantile cirrhosis.

Item Type:Article
Related URLs:
URLURL TypeDescription
Rees, D. C.0000-0003-4073-1185
Additional Information:© 1975 Nature Publishing Group. Received January 27; revised April 2, 1975. This research was supported by a grant from the National Institutes of Health. We thank Drs R. Talamo and J. Pierce for performing the electrophoresis in their laboratories and for providing serum from ZZ individuals.
Funding AgencyGrant Number
Issue or Number:5505
Record Number:CaltechAUTHORS:20150210-100937554
Persistent URL:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:54661
Deposited By: SWORD User
Deposited On:11 Feb 2015 00:00
Last Modified:03 Oct 2019 07:59

Repository Staff Only: item control page