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CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130

Ip, Nancy Y. and Nye, Steven H. and Boulton, Teri G. and Davis, Samuel and Taga, Tetsuya and Li, Yanping and Birren, Susan J. and Yasukawa, Kiyoshi and Kishimoto, Tadamitsu and Anderson, David J. and Stahl, Neil and Yancopoulos, George D. (1992) CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130. Cell, 69 (7). pp. 1121-1132. ISSN 0092-8674. doi:10.1016/0092-8674(92)90634-O. https://resolver.caltech.edu/CaltechAUTHORS:20150220-153308186

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Abstract

Ciliary neurotrophic factor (CNTF) has a variety of actions within the nervous system. While some of the actions of leukemia inhibitory factor (LIF) on neurons resemble those of CNTF, LIF also has broad actions outside of the nervous system that in many cases mimic those of interleukin-6 (IL-6). Comparison of the tyrosine phosphorylations and gene activations induced by CNTF and LIF in neuron cell lines reveals that they are indistinguishable and also very similar to signaling events that characterize LIF and IL-6 responses in hematopoietic cells. We provide a basis for the overlapping actions of these three factors by demonstrating that the shared CNTF and LIF signaling pathways involve the IL-6 signal transducing receptor component gp130. Thus, the receptor system for CNTF is surprisingly unlike those used by the nerve growth factor family of neurotrophic factors, but is instead related to those used by a subclass of hematopoietic cytokines.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/0092-8674(92)90634-ODOIArticle
http://www.sciencedirect.com/science/article/pii/009286749290634OPublisherArticle
ORCID:
AuthorORCID
Anderson, David J.0000-0001-6175-3872
Additional Information:© 1992 by Cell Press. Received March 6, 1992; Revised April 22, 1992. We thank Drs. L. S. Schleifer. M. E. Furth, and T. H. Aldrich and the entire Discovery group at Regeneron for their enthusiastic support and insightful scientific input. We also thank L. Pan, J. McClain, K. Mattsson, N. Lindsay, J. Ciliberti, and L. Defeo for technical assistance, Dr. M. J. Macchi for cell culture, Dr. B. Hoffmann-Liebermann for providing us with Ml cells, Dr. L. Greene for the tisll probe, and Drs. A. Miyajima. H. Gascan, and R. Wall for helpful discussions. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 USC Section 1734 solely to indicate this fact.
Funders:
Funding AgencyGrant Number
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Issue or Number:7
DOI:10.1016/0092-8674(92)90634-O
Record Number:CaltechAUTHORS:20150220-153308186
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150220-153308186
Official Citation:Ip, N. Y., Nye, S. H., Boulton, T. G., Davis, S., Taga, T., Li, Y., . . . Yancopoulos, G. D. (1992). CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130. Cell, 69(7), 1121-1132. doi: http://dx.doi.org/10.1016/0092-8674(92)90634-O
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:55073
Collection:CaltechAUTHORS
Deposited By: Joanne McCole
Deposited On:24 Feb 2015 19:58
Last Modified:10 Nov 2021 20:41

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