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Mammalian achaete-scute Homolog 1 Is Required for the Early Development of Olfactory and Autonomic Neurons

Guillemot, François and Lo, Li-Ching and Johnson, Jane A. and Auerbach, Anna and Anderson, David J. and Joyner, Alexandra L. (1993) Mammalian achaete-scute Homolog 1 Is Required for the Early Development of Olfactory and Autonomic Neurons. Cell, 75 (3). pp. 463-476. ISSN 0092-8674. doi:10.1016/0092-8674(93)90381-Y.

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The mouse Mash-1 gene, like its Drosophila homologs of the achaete-scute complex (AS-C), encodes a transcription factor expressed in neural precursors. We created a null allele of this gene by homologous recombination in embryonic stem cells. Mice homozygous for the mutation die at birth with apparent breathing and feeding defects. The brain and spinal cord of the mutants appear normal, but their olfactory epithelium and sympathetic, parasympathetic, and enteric ganglia are severely affected. In the olfactory epithelium, neuronal progenitors die at an early stage, whereas the nonneuronal supporting cells are present. In sympathetic ganglia, the mutation arrests the development of neuronal precursors, preventing the generation of sympathetic neurons, but does not affect glial precursor cells. These observations suggest that Mash-1, like its Drosophila homologs of the AS-C, controls a basic operation in development of neuronal progenitors in distinct neural lineages.

Item Type:Article
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Johnson, Jane A.0000-0001-9808-7172
Anderson, David J.0000-0001-6175-3872
Additional Information:© 1993 by Cell Press. Received 11 June 1993, Revised 17 August 1993, Available online 19 April 2004. We gratefully acknowledge K. Harpal for advice and assistance with histological procedures; Drs. T. Edlund, E. E. Geisert, T. Jessell, A. Klar, R. Klein, F. L. Margolis, B. Motro, V. Pachnis, and M. Tessier-Lavigne for the gilts of probes and antibodies; and Drs. A. Calof, C. C. Hui, and B. Motroforcritical reading of the manuscript. We thank B. N. Yoshida for his contributions to the early stages of this work (Anderson laboratory). This research was funded by grants from the National Cancer Institute of Canada and Bristol-Myers Squibb Limited to A. L. J. F. G. was supported by the Medical Research Council (MRC) of Canada and J. E. J. by a Young Investigator's Award from the National Neurofibromatosis Foundation. D. J. A. is an Associate Investigator of the Howard Hughes Medical Institute. A. L. J. is an MAC Scientist and a Howard Hughes International Scholar.
Funding AgencyGrant Number
National Cancer Institute of CanadaUNSPECIFIED
Bristol-Myers SquibbUNSPECIFIED
Medical Research Council (MRC) CanadaUNSPECIFIED
National Neurofibromatosis FoundationUNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Issue or Number:3
Record Number:CaltechAUTHORS:20150224-085353453
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Official Citation:François Guillemot, Li-Ching Lo, Jane E. Johnson, Anna Auerbach, David J. Anderson, Alexandra L. Joyner, Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons, Cell, Volume 75, Issue 3, 5 November 1993, Pages 463-476, ISSN 0092-8674, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:55142
Deposited By: Ruth Sustaita
Deposited On:24 Feb 2015 20:00
Last Modified:10 Nov 2021 20:42

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