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Evidence That Enteric Neurons May Derive from the Sympathoadrenal Lineage

Carnahan, Josette F. and Anderson, David J. and Patterson, Paul H. (1991) Evidence That Enteric Neurons May Derive from the Sympathoadrenal Lineage. Developmental Biology, 148 (2). pp. 552-561. ISSN 0012-1606. https://resolver.caltech.edu/CaltechAUTHORS:20150224-130834849

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Abstract

The first neurons that differentiate in the embryonic foregut of mammals transiently express catecholamine biosynthetic enzymes and accumulate catecholamine. Since this transmitter is found predominantly in cells of the sympathoadrenal (SA) lineage, it has been suggested that enteric and sympathetic neurons may derive from the same progenitor. Enteric neurons would then lose the catecholamine phenotype during further development, as the two lineages diverge. We have further investigated this possibility using the SA1 monoclonal antibody that binds selectively to SA progenitor cells in the embryonic rat. We find that SA1 binds to the tyrosine hydroxylase^+, neurofilament^+, and SCG10^+ cells of the Embryonic Day 14.5 (E14.5) rat foregut. We also find that a marker for later neuronal differentiation in the SA lineage, B2, also appears in the myenteric plexus concomitant with the loss of SA1 staining. Thus, at least some enteric neuronal precursors may exhibit the SA1 → B2 antigenic switch previously observed in developing sympathetic neurons at E14.5. SA1 staining in the foregut partially overlaps with staining for neuropeptide Y, vasoactive intestinal polypeptide, and serotonin. These results support the hypothesis that enteric and sympathetic neurons derive from a common progenitor and that as the markers for the SA lineage are down-regulated, the many types of enteric neurons begin to differentiate.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/0012-1606(91)90273-6DOIArticle
http://www.sciencedirect.com/science/article/pii/0012160691902736PublisherArticle
Additional Information:© 1991 by Academic Press. Inc. Accepted 29 August 1991. This work was supported by NIH Grant NS23476 to D.J.A., and by NINDS (Javits Neuroscience Investigator Award) and McKnight Foundation Neuroscience Research Project Awards to P.H.P. D.J.A. is an Assistant Investigator of the Howard Hughes Medical Institute.
Funders:
Funding AgencyGrant Number
NIHNS23476
NINDS (Javits Neuroscience Investigator Award)UNSPECIFIED
McKnight FoundationUNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Issue or Number:2
Record Number:CaltechAUTHORS:20150224-130834849
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150224-130834849
Official Citation:Josette F. Carnahan, David J. Anderson, Paul H. Patterson, Evidence that enteric neurons may derive from the sympathoadrenal lineage, Developmental Biology, Volume 148, Issue 2, December 1991, Pages 552-561, ISSN 0012-1606, http://dx.doi.org/10.1016/0012-1606(91)90273-6. (http://www.sciencedirect.com/science/article/pii/0012160691902736)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:55153
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:24 Feb 2015 22:53
Last Modified:03 Oct 2019 08:03

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