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A Schwann cell antigen recognized by monoclonal antibody 217c is the rat low-affinity nerve growth factor receptor

Stemple, Derek L. and Anderson, David J. (1991) A Schwann cell antigen recognized by monoclonal antibody 217c is the rat low-affinity nerve growth factor receptor. Neuroscience Letters, 124 (1). pp. 57-60. ISSN 0304-3940. https://resolver.caltech.edu/CaltechAUTHORS:20150224-133311656

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Abstract

Monoclonal antibody 217c was generated against an antigen expressed on the rat glial cell line, C6 glioma. 217c has been shown to recognize Schwann cells in mixed cultures as well as in tissue sections and has been used to identify Schwann cells independent of other markers, such as monoclonal antibody 192-IgG, which recognizes the rat low affinity nerve growth factor (NGF) receptor. Here we show that the antigen recognized by 217c is the rat low-affinity NGF receptor. This indicates that monoclonal antibodies 192-IgG and 217c are not independent markers and therefore that additional criteria need to be used for the identification of Schwann cells early in development.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/0304-3940(91)90821-ADOIArticle
http://www.sciencedirect.com/science/article/pii/030439409190821APublisherArticle
Additional Information:© 1991 Elsevier Scientific Publishers Ireland Ltd. Received 15 November 1990, Revised 3 December 1990, Accepted 5 December 1990. The authors would like to express their gratitude to Moses V. Chao for providing the LpMVR and Ltk-cell lines, to Jean de Vellis for providing the 217c antibody, to Eugene M. Johnson for providing the 192-IgG antibody and to Ms. Rochelle A. Diamond for the FACS analysis. This work is supported by NIH Grant NS-23476 and an NSF Presidential Young Investigator Award. D.J.A. is an Assistant Investigator of the Howard Hughes Medical Institute.
Funders:
Funding AgencyGrant Number
NIHNS-23476
NSF Presidential Young Investigator AwardUNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Subject Keywords:Schwann cell; NGF receptor; 217c; 192-IgG; RAN-1
Issue or Number:1
Record Number:CaltechAUTHORS:20150224-133311656
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150224-133311656
Official Citation:Derek L Stemple, David J Anderson, A Schwann cell antigen recognized by monoclonal antibody 217c is the rat low-affinity nerve growth factor receptor, Neuroscience Letters, Volume 124, Issue 1, 11 March 1991, Pages 57-60, ISSN 0304-3940, http://dx.doi.org/10.1016/0304-3940(91)90821-A. (http://www.sciencedirect.com/science/article/pii/030439409190821A)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:55155
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:24 Feb 2015 22:52
Last Modified:03 Oct 2019 08:03

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