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Silencing is golden: negative regulation in the control of neuronal gene transcription

Schoenherr, Christopher J. and Anderson, David J. (1995) Silencing is golden: negative regulation in the control of neuronal gene transcription. Current Opinion in Neurobiology, 5 (5). pp. 566-571. ISSN 0959-4388. doi:10.1016/0959-4388(95)80060-3.

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Recent work has identified negative-acting DNA regulatory elements that function to prevent the expression of neuronal genes in non-neuronal cell types or in inappropriate neuronal subtypes. In some cases, the protein factors that interact with these silencer elements have been isolated and characterized. For example, the recently cloned silencer-binding factor NRSF/REST is a novel zinc-finger protein that interacts with silencer elements in a number of neuron-specific genes. These data suggest that negative regulation plays a major role in determining the diverse patterns of gene expression within the nervous system.

Item Type:Article
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Anderson, David J.0000-0001-6175-3872
Additional Information:© 1995 Current Biology Ltd. Available online 11 February 2002. Portions of the work cited from the authors laboratory was supported by NIH grant NS23476. D.J. Anderson is an Associate Investigator of the Howard Hughes Medical Institute.
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Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Issue or Number:5
Record Number:CaltechAUTHORS:20150225-105127395
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Official Citation:Christopher J Schoenherr, David J Anderson, Silencing is golden: negative regulation in the control of neuronal gene transcription, Current Opinion in Neurobiology, Volume 5, Issue 5, October 1995, Pages 566-571, ISSN 0959-4388, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:55192
Deposited By: Ruth Sustaita
Deposited On:25 Feb 2015 19:02
Last Modified:10 Nov 2021 20:42

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