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Mammalian BarH Homologue Is a Potential Regulator of Neural bHLH Genes

Saito, Tetsuichiro and Sawamoto, Kazunobu and Okano, Hideyuki and Anderson, David J. and Mikoshiba, Katsuhiko (1998) Mammalian BarH Homologue Is a Potential Regulator of Neural bHLH Genes. Developmental Biology, 199 (2). pp. 216-225. ISSN 0012-1606. doi:10.1006/dbio.1998.8889.

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Vertebrate neurogenesis involves sequential actions of transcription factors.neurogenins,encoding Atonal-related bHLH transcription factors, function as neuronal determination genes inXenopus. neurogeninsand another bHLH factor gene,Mash1,are expressed in distinct subsets or areas of cells giving rise to neurons, suggesting that these genes play important roles to generate distinct populations of neurons. A mammalian homologue of BarH(MBH1) is expressed in a complementary pattern to Mash1expression in the developing nervous system likeneurogenins.Forced expression of MBH1down-regulates expression of Mash1and up-regulatesneurogenin2/Math4A, a member of neurogenins,in P19 cells during neuronal differentiation. This suggests thatMBH1is a potential regulator of mammalian neural bHLH genes, thereby establishing distinct pathways of neuronal differentiation.

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Anderson, David J.0000-0001-6175-3872
Additional Information:© 1998 Academic Press. Received 10 December 1997, Accepted 25 February 1998, Available online 2 May 2002. This work was initiated in the laboratory of D.J.A. and completed at RIKEN. We thank Dr. Qiufu Ma for providing neurogenins’ probes. T.S. is a Special Researcher of the Basic Science Program at RIKEN. D.J.A. is an Investigator of the Howard Hughes Medical Institute.
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Official Citation:Tetsuichiro Saito, Kazunobu Sawamoto, Hideyuki Okano, David J. Anderson, Katsuhiko Mikoshiba, Mammalian BarH Homologue Is a Potential Regulator of Neural bHLH Genes, Developmental Biology, Volume 199, Issue 2, 15 July 1998, Pages 216-225, ISSN 0012-1606, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:55207
Deposited By: Ruth Sustaita
Deposited On:25 Feb 2015 22:44
Last Modified:10 Nov 2021 20:43

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