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Functionally Related Motor Neuron Pool and Muscle Sensory Afferent Subtypes Defined by Coordinate ETS Gene Expression

Lin, Jonathan H. and Saito, Tetsuichiro and Anderson, David J. and Lance-Jones, Cynthia and Jessell, Thomas M. and Arber, Silvia (1998) Functionally Related Motor Neuron Pool and Muscle Sensory Afferent Subtypes Defined by Coordinate ETS Gene Expression. Cell, 95 (3). pp. 393-407. ISSN 0092-8674. http://resolver.caltech.edu/CaltechAUTHORS:20150225-144043050

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Abstract

Motor function depends on the formation of selective connections between sensory and motor neurons and their muscle targets. The molecular basis of the specificity inherent in this sensory-motor circuit remains unclear. We show that motor neuron pools and subsets of muscle sensory afferents can be defined by the expression of ETS genes, notably PEA3 and ER81. There is a matching in PEA3 and ER81 expression by functionally interconnected sensory and motor neurons. ETS gene expression by motor and sensory neurons fails to occur after limb ablation, suggesting that their expression is coordinated by signals from the periphery. ETS genes may therefore participate in the development of selective sensory-motor circuits in the spinal cord.


Item Type:Article
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http://dx.doi.org/10.1016/S0092-8674(00)81770-5DOIArticle
http://www.sciencedirect.com/science/article/pii/S0092867400817705PublisherArticle
Additional Information:© 1998 Cell Press. Received 2 July 1998, Revised 10 September 1998, Available online 29 September 2000. We are indebted to E. Frank for discussions on sensory-motor specificity and comments on the manuscript. L. Landmesser and M. Hollyday provided insight into motor neuron organization and function. We thank S. Pfaff and T. Tsuchida for participation in the initial studies on ETS expression, J. Gogos for help with the statistical analysis, J. Hassell for information on ETS genes and reagents, S. Morton for help in antibody generation, L. Reichardt for TrkC and TrkA antibodies, and M. Ensini and C. Stern for guidance on retrograde labeling and limb ablation. We are grateful to R. Axel for comments on the manuscript, and K. MacArthur and I. Schieren provided excellent assistance in its preparation. J. H. L. was supported by a training grant from the NIH. S. A. was supported by a HFSP Fellowship. T. M. J. is supported by grants from the NIH. C. L. J. is supported by NIH grant HD25676. T. M. J. and D. J. A. are Investigators of the Howard Hughes Medical Institute.
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Funding AgencyGrant Number
NIHUNSPECIFIED
HFSP FellowshipUNSPECIFIED
NIHHD25676
Record Number:CaltechAUTHORS:20150225-144043050
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20150225-144043050
Official Citation:Jonathan H Lin, Tetsuichiro Saito, David J Anderson, Cynthia Lance-Jones, Thomas M Jessell, Silvia Arber, Functionally Related Motor Neuron Pool and Muscle Sensory Afferent Subtypes Defined by Coordinate ETS Gene Expression, Cell, Volume 95, Issue 3, 30 October 1998, Pages 393-407, ISSN 0092-8674, http://dx.doi.org/10.1016/S0092-8674(00)81770-5. (http://www.sciencedirect.com/science/article/pii/S0092867400817705)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:55209
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:25 Feb 2015 22:54
Last Modified:25 Feb 2015 22:54

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