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Identification of neurogenin, a Vertebrate Neuronal Determination Gene

Ma, Qiufu and Kintner, Chris and Anderson, David J. (1996) Identification of neurogenin, a Vertebrate Neuronal Determination Gene. Cell, 87 (1). pp. 43-52. ISSN 0092-8674. https://resolver.caltech.edu/CaltechAUTHORS:20150225-151228117

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Abstract

Several bHLH proteins are involved in vertebrate neurogenesis, but those controlling early stages of neuronal determination have not yet been identified. Here we describe a novel, NeuroD-related bHLH protein, NEUROGENIN, whose expression precedes that of NeuroD in both mouse and Xenopus. Expression of Xenopus NEUROGENIN-related-1 (X-NGNR-1) defines the three prospective territories of primary neurogenesis. Overexpression of X-NGNR-1 (or NEUROGENIN) induces ectopic neurogenesis and ectopic expression of XNeuroD mRNA. Endogenous X-ngnr-1 expression becomes restricted to subsets of cells by lateral inhibition, mediated by X-Delta-1 and X-Notch. The properties of X-NGNR-1 are thus analogous to those of the Drosophila proneural genes, suggesting that it functions as a vertebrate neuronal determination factor.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/S0092-8674(00)81321-5DOIArticle
http://www.sciencedirect.com/science/article/pii/S0092867400813215PublisherArticle
Additional Information:© 1996 Cell Press. Received 24 June 1996, Revised 16 August 1996, Available online 3 October 2000. We are grateful to Andres Collazo and Suzanne Cohen-Cory (Fraser laboratory, Caltech) for providing Xenopus embryos for in situ analysis and to Wenying Shou (Dunphy lab) for providing St. 12 and 22 Xenopus embryo cDNAs. We thank Amy Greenwood and Alice Paquette for assistance in dissecting embryonic DRGs, Andy Groves for performing pilot in situ hybridization experiments, Steve Padilla and Ling Wang for technical assistance, and Jacqueline Lee for providing the Xenopus NeuroD cDNA probe. We thank S. Fraser, B. Wold, R. Axel, and K. Zinn for their comments on the manuscript, and the Seaver Institute for support. D. J. A. is an Associate Investigator of the Howard Hughes Medical Institute. C. K. was supported by a grant from the NIH.
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Seaver Institute UNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
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Issue or Number:1
Record Number:CaltechAUTHORS:20150225-151228117
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150225-151228117
Official Citation:Qiufu Ma, Chris Kintner, David J Anderson, Identification of neurogenin, a Vertebrate Neuronal Determination Gene, Cell, Volume 87, Issue 1, 4 October 1996, Pages 43-52, ISSN 0092-8674, http://dx.doi.org/10.1016/S0092-8674(00)81321-5. (http://www.sciencedirect.com/science/article/pii/S0092867400813215)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:55213
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:26 Feb 2015 00:01
Last Modified:03 Oct 2019 08:03

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