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X-MyT1, a Xenopus C2HC-Type Zinc Finger Protein with a Regulatory Function in Neuronal Differentiation

Bellefroid, Eric J. and Bourguignon, Catherine and Hollemann, Thomas and Ma, Qiufu and Anderson, David J. and Kintner, Chris and Pieler, Tomas (1996) X-MyT1, a Xenopus C2HC-Type Zinc Finger Protein with a Regulatory Function in Neuronal Differentiation. Cell, 87 (7). pp. 1191-1202. ISSN 0092-8674. doi:10.1016/S0092-8674(00)81815-2.

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X-MyT1 is a C2HC-type zinc finger protein that we find to be involved in the primary selection of neuronal precursor cells in Xenopus. Expression of this gene is positively regulated by the bHLH protein X-NGNR-1 and negatively regulated by the Notch/Delta signal transduction pathway. X-MyT1 is able to promote ectopic neuronal differentiation and to confer insensitivity to lateral inhibition, but only in cooperation with bHLH transcription factors. Inhibition of X-MyT1 function inhibits normal neurogenesis as well as ectopic neurogenesis caused by overexpression of X-NGNR-1. On the basis of these findings, we suggest that X-MyT1 is a novel, essential element in the cascade of events that allows cells to escape lateral inhibition and to enter the pathway that leads to terminal neuronal differentiation.

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Anderson, David J.0000-0001-6175-3872
Additional Information:© 1996 by Cell Press. Received 8 August 1996, Revised 11 November 1996, Available online 3 October 2000. We are grateful to Regina Buhl, Tina Berneking, and Michaela Beusse-Jendraszek for expert technical assistance. E. J. B thanks Drs. Nancy Papalopulu and Ajay Chitnis for helpful discussions. We also thank Drs. Jacqueline Lee, Peter Gruss, and T. Kornberg for generously providing DNA constructs. E. J. B. is recipient of a long-term EMBO fellowship. This work was supported by funds from the Deutsche Forschungsgemeinschaft to T. P.
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Deutsche Forschungsgemeinschaft (DFG)UNSPECIFIED
European Molecular Biology Organization (EMBO)UNSPECIFIED
Issue or Number:7
Record Number:CaltechAUTHORS:20150226-083820709
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Official Citation:Eric J Bellefroid, Catherine Bourguignon, Thomas Hollemann, Qiufu Ma, David J Anderson, Chris Kintner, Tomas Pieler, X-MyT1, a Xenopus C2HC-Type Zinc Finger Protein with a Regulatory Function in Neuronal Differentiation, Cell, Volume 87, Issue 7, 27 December 1996, Pages 1191-1202, ISSN 0092-8674, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:55237
Deposited By: Ruth Sustaita
Deposited On:26 Feb 2015 17:24
Last Modified:10 Nov 2021 20:43

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