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Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

Montagne, Axel and Barnes, Samuel R. and Sweeney, Melanie D. and Halliday, Matthew R. and Sagare, Abhay P. and Zhao, Zhen and Toga, Arthur W. and Jacobs, Russell E. and Liu, Collin Y. and Amezcua, Lilyana and Harrington, Michael G. and Chui, Helena C. and Law, Meng and Zlokovic, Berislav V. (2015) Blood-Brain Barrier Breakdown in the Aging Human Hippocampus. Neuron, 85 (2). pp. 296-302. ISSN 0896-6273. PMCID PMC4350773. https://resolver.caltech.edu/CaltechAUTHORS:20150226-120053528

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Abstract

The blood-brain barrier (BBB) limits entry of blood-derived products, pathogens, and cells into the brain that is essential for normal neuronal functioning and information processing. Post-mortem tissue analysis indicates BBB damage in Alzheimer’s disease (AD). The timing of BBB breakdown remains, however, elusive. Using an advanced dynamic contrast-enhanced MRI protocol with high spatial and temporal resolutions to quantify regional BBB permeability in the living human brain, we show an age-dependent BBB breakdown in the hippocampus, a region critical for learning and memory that is affected early in AD. The BBB breakdown in the hippocampus and its CA1 and dentate gyrus subdivisions worsened with mild cognitive impairment that correlated with injury to BBB-associated pericytes, as shown by the cerebrospinal fluid analysis. Our data suggest that BBB breakdown is an early event in the aging human brain that begins in the hippocampus and may contribute to cognitive impairment.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.neuron.2014.12.032DOIArticle
http://www.sciencedirect.com/science/article/pii/S0896627314011416PublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350773/PubMed CentralArticle
ORCID:
AuthorORCID
Barnes, Samuel R.0000-0002-1065-8442
Jacobs, Russell E.0000-0002-1382-8486
Harrington, Michael G.0000-0002-7923-8032
Zlokovic, Berislav V.0000-0002-6802-8232
Additional Information:© 2015 Elsevier Inc. Accepted 10 December 2014, Available online 21 January 2015. We would like to thank the National Institutes of Health for grants R37NS34467 (B.V.Z.), R37AG23084 (B.V.Z.), R01AG039452 (B.V.Z.), Zilkha Senior Scholar support (B.V.Z.), R21EB013456 (M.L.), UL1TR000130 (M.L.), L.K. Whittier Foundation (M.G.H), P50AG05142 (H.C.C.), 7P41EB015922 (A.W.T.), and EB000993 (R.E.J.). Author Contributions: A.M. and B.V.Z. designed research and analyzed and interpreted data; A.M., S.R.B., M.D.S., M.R.H., A.P.S., and Z.Z. performed experiments and analyzed data; A.M., S.R.B., and R.E.J. contributed to a new analytic software; C.Y.L., H.C.C., M.L., L.A., and M.G.H. recruited participants and performed and provided imaging scans; S.R.B., A.W.T., R.E.J., H.C.C., M.L., and M.G.H. provided critical reading of the manuscript; A.M. contributed to manuscript writing; and B.V.Z. wrote the manuscript.
Funders:
Funding AgencyGrant Number
NIHR37NS34467
NIHR37AG23084
NIHR01AG039452
Zilkha Senior ScholarR21EB013456
Zilkha Senior ScholarUL1TR000130
L. K. Whittier FoundationP50AG05142
L. K. Whittier Foundation7P41EB015922
L. K. Whittier FoundationEB000993
Issue or Number:2
PubMed Central ID:PMC4350773
Record Number:CaltechAUTHORS:20150226-120053528
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150226-120053528
Official Citation:Axel Montagne, Samuel R. Barnes, Melanie D. Sweeney, Matthew R. Halliday, Abhay P. Sagare, Zhen Zhao, Arthur W. Toga, Russell E. Jacobs, Collin Y. Liu, Lilyana Amezcua, Michael G. Harrington, Helena C. Chui, Meng Law, Berislav V. Zlokovic, Blood-Brain Barrier Breakdown in the Aging Human Hippocampus, Neuron, Volume 85, Issue 2, 21 January 2015, Pages 296-302, ISSN 0896-6273, http://dx.doi.org/10.1016/j.neuron.2014.12.032. (http://www.sciencedirect.com/science/article/pii/S0896627314011416)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:55261
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:26 Feb 2015 21:22
Last Modified:09 Mar 2020 13:19

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