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Olig genes and the genetic logic of CNS neural cell fate determination

Anderson, David J. and Choi, Gloria and Zhou, Qiao (2002) Olig genes and the genetic logic of CNS neural cell fate determination. Clinical Neuroscience Research, 2 (1-2). pp. 17-28. ISSN 1566-2772. doi:10.1016/S1566-2772(02)00014-2. https://resolver.caltech.edu/CaltechAUTHORS:20150304-113028618

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Abstract

The three fundamental cell types of the vertebrate CNS are neurons, astrocytes and oligodendrocytes. The molecular mechanisms that generate this basic triad remain poorly understood. Transcription factors in the basic helix-loop-helix (bHLH) family have been shown to play an important role in the fundamental choice between neuronal and glial fates, while homeodomain transcription factors have been shown to determine different aspects of neuronal subtype identity. However, the transcriptional control of the choice between oligodendrocyte and astrocyte fates has not been elucidated. Here we describe a novel family of bHLH factors, called Olig1 and Olig2, that is specifically expressed in oligodendrocyte precursors throughout the CNS. Genetic studies indicate that Olig1/2 promote motoneuron and suppress interneuron fates during the neurogenic phase of spinal cord development, while at later stages they promote the oligodendrocyte and suppress the astrocyte fates. In this way, these factors couple neuronal subtype specification to glial subtype specification. In conjunction with the proneural subclass of bHLH factors, such as the Neurogenins, Olig genes can define a simple combinatorial code that determines whether CNS progenitors will adopt neuronal, oligodendroglial or astroglial fates. This genetic logic offers a framework for understanding the basic mechanisms that generate the three fundamental cell types of the vertebrate CNS.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/S1566-2772(02)00014-2DOIArticle
http://www.sciencedirect.com/science/article/pii/S1566277202000142PublisherArticle
ORCID:
AuthorORCID
Anderson, David J.0000-0001-6175-3872
Additional Information:© 2002 Published by Association for Research in Nervous and Mental Disease. Available online 30 May 2002. We thank Tom Jessell, Ben Novitch, Charles Stiles, Richard Lu and David Rowitch for sharing unpublished data and reagents and for helpful discussions. D.J.A. is an Investigator of the Howard Hughes Medical Institute.
Funders:
Funding AgencyGrant Number
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Subject Keywords:Neurogenesis; Gliogenesis; Oligodendrocytes; Stem cells; Basic helix-loop-helix factors; Olig genes
Issue or Number:1-2
DOI:10.1016/S1566-2772(02)00014-2
Record Number:CaltechAUTHORS:20150304-113028618
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150304-113028618
Official Citation:Anderson, D. J., Choi, G., & Zhou, Q. (2002). Olig genes and the genetic logic of CNS neural cell fate determination. Clinical Neuroscience Research, 2(1–2), 17-28. doi: http://dx.doi.org/10.1016/S1566-2772(02)00014-2
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:55516
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:04 Mar 2015 22:51
Last Modified:10 Nov 2021 20:46

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