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The bHLH Transcription Factors OLIG2 and OLIG1 Couple Neuronal and Glial Subtype Specification

Zhou, Qiao and Anderson, David J. (2002) The bHLH Transcription Factors OLIG2 and OLIG1 Couple Neuronal and Glial Subtype Specification. Cell, 109 (1). pp. 61-73. ISSN 0092-8674. doi:10.1016/S0092-8674(02)00677-3. https://resolver.caltech.edu/CaltechAUTHORS:20150305-092413444

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Abstract

OLIG1 and OLIG2 are basic-helix-loop-helix (bHLH) transcription factors expressed in the pMN domain of the spinal cord, which sequentially generates motoneurons and oligodendrocytes. In Olig1/2 double-mutant mice, motoneurons are largely eliminated, and oligodendrocyte differentiation is abolished. Lineage tracing data suggest that Olig1−/−2−/− pMN progenitors instead generate V2 interneurons and then astrocytes. This apparent conversion likely reflects independent roles for OLIG1/2 in specifying motoneuron and oligodendrocyte fates. Olig genes therefore couple neuronal and glial subtype specification, unlike proneural bHLH factors that control the neuron versus glia decision. Our results suggest that in the spinal cord, Olig and proneural genes comprise a combinatorial code for the specification of neurons, astrocytes, and oligodendrocytes, the three fundamental cell types of the central nervous system.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/S0092-8674(02)00677-3DOIArticle
ORCID:
AuthorORCID
Anderson, David J.0000-0001-6175-3872
Additional Information:© 2002 Cell Press. Under an Elsevier user license. Received: November 28, 2001; Revised: February 13, 2002; Published online: March 11, 2002. We thank Drs. Richard Lu, Charles Stiles, and David Rowitch for communicating unpublished results and Tom Jessell for advice, reagents, helpful discussions, and critical comments on the manuscript. We are also grateful to Shirley Peace and Bruce Kennedy of the Caltech Transgenic Facility, Joana Yamada for technical assistance, and Gaby Mosconi for laboratory management. This work was supported by National Institutes of Health Grant RO1-NS23476. D.J.A. is an Investigator of the Howard Hughes Medical Institute.
Funders:
Funding AgencyGrant Number
NIHRO1-NS23476
Issue or Number:1
DOI:10.1016/S0092-8674(02)00677-3
Record Number:CaltechAUTHORS:20150305-092413444
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150305-092413444
Official Citation:Zhou, Q., & Anderson, D. J. (2002). The bHLH Transcription Factors OLIG2 and OLIG1 Couple Neuronal and Glial Subtype Specification. Cell, 109(1), 61-73. doi: http://dx.doi.org/10.1016/S0092-8674(02)00677-3
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:55533
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:05 Mar 2015 20:28
Last Modified:10 Nov 2021 20:46

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