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Allocrine Modulation of Feeding Behavior by the Sex Peptide of Drosophila

Carvalho, Gil B. and Kapahi, Pankaj and Anderson, David J. and Benzer, Seymour (2006) Allocrine Modulation of Feeding Behavior by the Sex Peptide of Drosophila. Current Biology, 16 (7). pp. 692-696. ISSN 0960-9822. PMCID PMC2745344. https://resolver.caltech.edu/CaltechAUTHORS:20150305-123010415

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Abstract

Mating elicits a dramatic reprogramming of female behavior in numerous insect species. In Drosophila, this postmating response (PMR) comprises increased egg-laying rate and reduced sexual receptivity and is controlled by the products of the male accessory glands, a family of ∼80 small peptides transferred in the male seminal fluid [1-9]. Here, we show that copulation strongly stimulates female food intake. Remarkably, this change is abolished if the males lack a single, small seminal protein, the Sex Peptide (SP). Ectopic expression of SP in virgin females mimics the effect of mating on feeding behavior, demonstrating that SP is the main agent controlling this behavioral paradigm. Our observations identify enhanced feeding behavior as a novel component of the Drosophila PMR and suggest that SP represents a molecular link between energy acquisition and reproductive investment.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.cub.2006.02.064DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745344PubMed CentralArticle
ORCID:
AuthorORCID
Anderson, David J.0000-0001-6175-3872
Additional Information:© 2006 Elsevier Ltd. Under an Elsevier user license. Received: December 8, 2005; Revised: February 14, 2006; Accepted: February 14, 2006; Published: April 3, 2006. We thank members of the Benzer lab, E. Kubli, and T. Aigaki for helpful discussions. This work was supported by a Lawrence L. and Audrey W. Ferguson Fellowship to G.B.C., a grant from the American Federation for Aging Research and a postdoctoral fellowship from the John Douglas French Foundation for Alzheimer’s Research to P.K., and grants to S.B. from the National Institutes of Health (AG16630, AG24366, and DK070154), the National Science Foundation (MCB-0418479), and the Ellison foundation.
Funders:
Funding AgencyGrant Number
Lawrence L. and Audrey W. Ferguson FellowshipUNSPECIFIED
American Federation for Aging ResearchUNSPECIFIED
John Douglas French Alzheimer’s FoundationUNSPECIFIED
NIHAG16630
NIHAG24366
NIHDK070154
NSFMCB-0418479
Ellison Medical FoundationUNSPECIFIED
Issue or Number:7
PubMed Central ID:PMC2745344
Record Number:CaltechAUTHORS:20150305-123010415
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150305-123010415
Official Citation:Carvalho, G. B., Kapahi, P., Anderson, D. J., & Benzer, S. (2006). Allocrine Modulation of Feeding Behavior by the Sex Peptide of Drosophila. Current Biology, 16(7), 692-696. doi: http://dx.doi.org/10.1016/j.cub.2006.02.064
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:55546
Collection:CaltechAUTHORS
Deposited By: Joanne McCole
Deposited On:06 Mar 2015 20:34
Last Modified:27 Mar 2020 21:48

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