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Genetic ablation of parathyroid glands reveals another source of parathyroid hormone

Günther, Thomas and Chen, Zhou-Feng and Kim, Jaesang and Priemel, Matthias and Rueger, Johannes M. and Amling, Michael and Moseley, Jane M. and Martin, T. John and Anderson, David J. and Karsenty, Gerard (2000) Genetic ablation of parathyroid glands reveals another source of parathyroid hormone. Nature, 406 (6792). pp. 199-203. ISSN 0028-0836. https://resolver.caltech.edu/CaltechAUTHORS:20150306-100735649

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Abstract

The parathyroid glands are the only known source of circulating parathyroid hormone (PTH), which initiates an endocrine cascade that regulates serum calcium concentration. Glial cells missing (Gcm2), a mouse homologue of Drosophila Gcm, is the only transcription factor whose expression is restricted to the parathyroid glands. Here we show that Gcm2-deficient mice lack parathyroid glands and exhibit a biological hypoparathyroidism, identifying Gcm2 as a master regulatory gene of parathyroid gland development. Unlike PTH receptor-deficient mice, however, Gcm2-deficient mice are viable and fertile, and have only a mildly abnormal bone phenotype. Despite their lack of parathyroid glands, Gcm2-deficient mice have PTH serum levels identical to those of wild-type mice, as do parathyroidectomized wild-type animals. Expression and ablation studies identified the thymus, where Gcm1, another Gcm homologue, is expressed, as the additional, downregulatable source of PTH. Thus, Gcm2 deletion uncovers an auxiliary mechanism for the regulation of calcium homeostasis in the absence of parathyroid glands. We propose that this backup mechanism may be a general feature of endocrine regulation.


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http://dx.doi.org/10.1038/35018111DOIArticle
http://www.nature.com/nature/journal/v406/n6792/full/406199a0.htmlPublisherArticle
http://www.nature.com/nature/journal/v406/n6792/suppinfo/406199a0.htmlPublisherSupplementary Information
http://rdcu.be/coTdPublisherFree ReadCube access
Additional Information:© 2000 Macmillan Publishers Limited. Received 17 January 2000; Accepted 22 May 2000. G.K. thanks R. Behringer for his generosity. We thank R. Balling, R. Civitelli, C. Johner, H. Kronenberg, B. Lanske, J.Mclaughlin, H. Peters, L.D. Quarles and S. Rebalo for reagents and advice, A. Arnold for sharing unpublished information, and R. Behringer, H. Bellen, P. Hastings, C. Silve, H. Zoghbi and members of the Karsenty laboratory for critical reading of the manuscript. This work is supported by a grant from the MOD foundation to G.K. and NIH grants to G.K. and D.A. T.G. was supported by the Deutscher Akademischer Austauschdienst (DAAD). D.J.A. is an investigator of the Howard Hughes Medical Institute.
Funders:
Funding AgencyGrant Number
MOD foundationUNSPECIFIED
NIHUNSPECIFIED
Deutscher Akademischer Austauschdienst (DAAD)UNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Issue or Number:6792
Record Number:CaltechAUTHORS:20150306-100735649
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150306-100735649
Official Citation:Gunther, T., Chen, Z.-F., Kim, J., Priemel, M., Rueger, J. M., Amling, M., . . . Karsenty, G. (2000). Genetic ablation of parathyroid glands reveals another source of parathyroid hormone. [10.1038/35018111]. Nature, 406(6792), 199-203.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:55587
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:06 Mar 2015 21:16
Last Modified:03 Oct 2019 08:06

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