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Genes, lineages and the neural crest: a speculative review

Anderson, David J. (2000) Genes, lineages and the neural crest: a speculative review. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 355 (1399). pp. 953-964. ISSN 0962-8436. PMCID PMC1692804. doi:10.1098/rstb.2000.0631.

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Sensory and sympathetic neurons are generated from the trunk neural crest. The prevailing view has been that these two classes of neurons are derived from a common neural crest–derived progenitor that chooses between neuronal fates only after migrating to sites of peripheral ganglion formation. Here I reconsider this view in the light of new molecular and genetic data on the differentiation of sensory and autonomic neurons. These data raise several paradoxes when taken in the context of classical studies of the timing and spatial patterning of sensory and autonomic ganglion formation. These paradoxes can be most easily resolved by assuming that the restriction of neural crest cells to either sensory or autonomic lineages occurs at a very early stage, either before and/or shortly after they exit the neural tube.

Item Type:Article
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URLURL TypeDescription CentralArticle
Anderson, David J.0000-0001-6175-3872
Additional Information:© 2000 The Royal Society. I thank past and present members of my laboratory who have contributed data and ideas to our studies of the neural crest. These include Derek Stemple, Nirao Shah, Liching Lo, Amy Greenwood, PatWhite, Sherry Perez, Jane Johnson, Lukas Sommer, Joseph Verdi and Qiufu Ma. The perspective presented here is the author’s and is not necessarily representative of these other individuals. I am grateful to Amy Greenwood for helpful comments on the manuscript. The author is an Investigator of the Howard Hughes Medical Institute.
Funding AgencyGrant Number
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Subject Keywords:neural crest; neurogenesis; cell lineage; sensory neurons; autonomic neurons
Issue or Number:1399
PubMed Central ID:PMC1692804
Record Number:CaltechAUTHORS:20150306-142632018
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Official Citation:Anderson D. J. (2000). Genes, lineages and the neural crest: a speculative review. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 355(1399), 953–964.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:55611
Deposited On:07 Mar 2015 00:34
Last Modified:10 Nov 2021 20:47

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