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A Steroid-Conjugated Contrast Agent for Magnetic Resonance Imaging of Cell Signaling

Lee, Jiyoun and Zylka, Mark J. and Anderson, David J. and Burdette, Joanna E. and Woodruff, Teresa K. and Meade, Thomas J. (2005) A Steroid-Conjugated Contrast Agent for Magnetic Resonance Imaging of Cell Signaling. Journal of the American Chemical Society, 127 (38). pp. 13164-13166. ISSN 0002-7863. doi:10.1021/ja051294x. https://resolver.caltech.edu/CaltechAUTHORS:20150310-113015676

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Abstract

We have synthesized the first steroid hormone−MR contrast agent conjugate designed to track the cell signaling process upon binding to a gene switch system. The derivative has a high relaxivity and when tested in vitro is active as a progesterone antagonist (RU-486). By combining a transcriptional system and a noninvasive imaging technology, such as MRI, it would be a powerful tool to research the cell signaling pathway in vivo.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/ja051294xDOIArticle
http://pubs.acs.org/doi/abs/10.1021/ja051294xPublisherArticle
http://pubs.acs.org/doi/suppl/10.1021/ja051294xPublisherSupporting Information
ORCID:
AuthorORCID
Anderson, David J.0000-0001-6175-3872
Additional Information:© 2005 American Chemical Society. Received March 1, 2005. We thank Scott Fraser for helpful discussions, Keith MacRenaris for ICP-MS analysis, Steve Bull for image acquisition and T_1 analysis, and Ken Korach for providing PRE-luciferase. This work is supported by the National Institutes of Health (5RO1 A147003, DOD 91008600, and PO1HD021921), and by Northwestern University Reproductive Biology Training Grant T32 HD007068.
Funders:
Funding AgencyGrant Number
NIH5RO1 A147003
NIHDOD 91008600
NIHPO1HD021921
Northwestern University Reproductive Biology Training GrantT32 HD007068
Issue or Number:38
DOI:10.1021/ja051294x
Record Number:CaltechAUTHORS:20150310-113015676
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150310-113015676
Official Citation:Lee, J., Zylka, M. J., Anderson, D. J., Burdette, J. E., Woodruff, T. K., & Meade, T. J. (2005). Journal of the American Chemical Society, 127(38), 13164-13166. doi: 10.1021/ja051294x
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:55669
Collection:CaltechAUTHORS
Deposited By: Joanne McCole
Deposited On:10 Mar 2015 18:48
Last Modified:10 Nov 2021 20:48

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