Barton, Jacqueline K. (2014) DNA signaling among proteins with iron-sulfur clusters. Abstracts of Papers of the American Chemical Society, 247 . 440-INOR. ISSN 0065-7727. https://resolver.caltech.edu/CaltechAUTHORS:20150316-095808555
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Abstract
DNA-mediated charge transport can yield redox chem. over long mol. distances in a reaction that reports on the integrity of the intervening base stack. Moreover, increasingly, proteins involved in DNA replication and repair have been found to contain 4Fe-4S clusters, common redox cofactors in biol. DNA- modified electrodes have been utilized to det. redox potentials for these metalloproteins bound to DNA; this electrochem. establishes the ability of the metalloproteins to carry out redox chem. at physiol. potentials in the DNA- bound form. Studies are also described to characterize how these DNA-binding proteins contg. 4Fe-4S clusters may utilize DNA charge transport chem. for long range redox signaling.
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Additional Information: | © 2014 American Chemical Society. | ||||||
Record Number: | CaltechAUTHORS:20150316-095808555 | ||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20150316-095808555 | ||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||
ID Code: | 55778 | ||||||
Collection: | CaltechAUTHORS | ||||||
Deposited By: | Tony Diaz | ||||||
Deposited On: | 16 Mar 2015 17:39 | ||||||
Last Modified: | 03 Oct 2019 08:08 |
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