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DNA signaling among proteins with iron-sulfur clusters

Barton, Jacqueline K. (2014) DNA signaling among proteins with iron-sulfur clusters. Abstracts of Papers of the American Chemical Society, 247 . 440-INOR. ISSN 0065-7727 . http://resolver.caltech.edu/CaltechAUTHORS:20150316-095808555

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Abstract

DNA-mediated charge transport can yield redox chem. over long mol. distances in a reaction that reports on the integrity of the intervening base stack. Moreover, increasingly, proteins involved in DNA replication and repair have been found to contain 4Fe-4S clusters, common redox cofactors in biol. DNA- modified electrodes have been utilized to det. redox potentials for these metalloproteins bound to DNA; this electrochem. establishes the ability of the metalloproteins to carry out redox chem. at physiol. potentials in the DNA- bound form. Studies are also described to characterize how these DNA-binding proteins contg. 4Fe-4S clusters may utilize DNA charge transport chem. for long range redox signaling.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://www.acs.org/content/acs/en/meetings/spring-2014.htmlOrganizationConference Website
ORCID:
AuthorORCID
Barton, Jacqueline K.0000-0001-9883-1600
Additional Information:© 2014 American Chemical Society.
Record Number:CaltechAUTHORS:20150316-095808555
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20150316-095808555
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:55778
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:16 Mar 2015 17:39
Last Modified:16 Mar 2015 17:39

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