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Hebbian STDP in mushroom bodies facilitates the synchronous flow of olfactory information in locusts

Cassenaer, Stijn and Laurent, Gilles (2007) Hebbian STDP in mushroom bodies facilitates the synchronous flow of olfactory information in locusts. Nature, 448 (7154). pp. 709-713. ISSN 0028-0836. doi:10.1038/nature05973. https://resolver.caltech.edu/CaltechAUTHORS:20150317-080605344

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Abstract

Odour representations in insects undergo progressive transformations and decorrelatio from the receptor array to the presumed site of odour learning, the mushroom body. There, odours are represented by sparse assemblies of Kenyon cells in a large population. Using intracellular recordings in vivo, we examined transmission and plasticity at the synapse made by Kenyon cells onto downstream targets in locusts. We find that these individual synapses are excitatory and undergo hebbian spike-timing dependent plasticity (STDP) on a ±25 ms timescale. When placed in the context of odour-evoked Kenyon cell activity (a 20-Hz oscillatory population discharge), this form of STDP enhances the synchronization of the Kenyon cells’ targets and thus helps preserve the propagation of the odour-specific codes through the olfactory system.


Item Type:Article
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URLURL TypeDescription
http://dx.doi.org/10.1038/nature05973DOIArticle
http://www.nature.com/nature/journal/v448/n7154/full/nature05973.htmlPublisherArticle
http://www.nature.com/nature/journal/v448/n7154/suppinfo/nature05973.htmlPublisherSupplementary Information
http://rdcu.be/ck8XPublisherFree ReadCube access
ORCID:
AuthorORCID
Laurent, Gilles0000-0002-2296-114X
Additional Information:© 2007 Nature Publishing Group. Received 26 April; accepted 1 June 2007. Published online 20 June 2007. This work was supported by an NIH training grant, grants from the NIDCD, and the Lawrence Hanson Fund. We thank E. Schuman, I. Fiete, M. Murthy, M. Papadopoulou, O. Mazor, V. Jayaraman and the reviewers for their helpful comments.
Funders:
Funding AgencyGrant Number
NIH Training GrantUNSPECIFIED
National Institute on Deafness and Other Communication Disorders (NIDCD)UNSPECIFIED
Lawrence Hanson FundUNSPECIFIED
Issue or Number:7154
DOI:10.1038/nature05973
Record Number:CaltechAUTHORS:20150317-080605344
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150317-080605344
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:55826
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:17 Mar 2015 16:16
Last Modified:10 Nov 2021 20:50

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