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In vivo functional cooperation of insulin-like growth factor I and leukemia inhibitory factor studied in mutant mice

de Pablo, Flora and Fernández-Moreno, Carmen and Vicario-Abejόn, Carlos and Patterson, Paul H. and Pichel, Jose G. (2000) In vivo functional cooperation of insulin-like growth factor I and leukemia inhibitory factor studied in mutant mice. Developmental Biology, 222 (1). p. 280. ISSN 0012-1606. doi:10.1016/S0012-1606(00)80002-0.

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Leukemia Inhibitory Factor (LIF) and Insulin like growth factor I (IGFI) are multifunctional proteins that regulate cell survival, proliferation or differentiation of cell types of several lineages. They are expressed in mammalian development in lung, muscle, skin, the nervous system and other tissues. Previous results indicate cross-talk between the signalling mediators of L1F (STAT proteins) and IGF-I (1RS proteins). To study a possible cooperation in vivo between LIF and IGF-I, heterocygous mutant mice (kindly provided by C. L. Stewart and A. Efstratiadis respectively) were intercrossed. Mortality before weaning was low for LIF-nult mice (13%) whereas, as previously reported, it was significant for IGF-Iqmll mice (62%). All double-null mutant mice died at birth suggesting a cooperation of LIF and tGF-I in vital functions, as well as sustaining embryonic growth. In E18.5, the deficit in LIF aggravates the lung, muscle, and skin abnormalities present in IGF-I deficient mice. Whereas most of the central nervous system areas appeared grossly normal in single and double mutants, there was a 70% depletion of mitral neurons in the olfactory bulb, depending almost exclusively of IGF-I deficit. Thus, these two growth factors have cooperative and independent actions in different tissues during development.

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Additional Information:© 2000 by Academic Press.
Issue or Number:1
Record Number:CaltechAUTHORS:20150318-101758095
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Official Citation:Abstracts, Developmental Biology, Volume 222, Issue 1, 1 June 2000, Pages 223-283, ISSN 0012-1606, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:55884
Deposited By: Ruth Sustaita
Deposited On:18 Mar 2015 19:36
Last Modified:10 Nov 2021 20:51

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