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Launching the T-cell-lineage developmental programme

Rothenberg, Ellen V. and Moore, Jonathan E. and Yui, Mary A. (2008) Launching the T-cell-lineage developmental programme. Nature Reviews. Immunology, 8 (1). pp. 9-21. ISSN 1474-1733. PMCID PMC3131407. doi:10.1038/nri2232.

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Multipotent blood progenitor cells enter the thymus and begin a protracted differentiation process in which they gradually acquire T-cell characteristics while shedding their legacy of developmental plasticity. Notch signalling and basic helix-loop-helix E-protein transcription factors collaborate repeatedly to trigger and sustain this process throughout the period leading up to T-cell lineage commitment. Nevertheless, the process is discontinuous with separately regulated steps that demand roles for additional collaborating factors. This Review discusses new evidence on the coordination of specification and commitment in the early T-cell pathway; effects of microenvironmental signals; the inheritance of stem-cell regulatory factors; and the ensemble of transcription factors that modulate the effects of Notch and E proteins, to distinguish individual stages and to polarize T-cell-lineage fate determination.

Item Type:Article
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URLURL TypeDescription DOIArticle ReadCube access CentralArticle
Rothenberg, Ellen V.0000-0002-3901-347X
Yui, Mary A.0000-0002-3136-2181
Additional Information:© 2008 Nature Publishing Group. The authors wish to thank T. Graf, H. Kawamoto, B. Kee, C. Murre, H. Petrie and N. Speck for valuable discussions and generous sharing of unpublished results. We apologize to many authors whose work we could not adequately cite. We also thank members of the Rothenberg group for collegial interchange, advice and permission to cite unpublished work, and N. Feng, R. Butler and D. Perez for technical support. The authors were supported by grants from the National Institutes of Health (NIH), USA, to E.V.R. (R01 CA90233 and R01 CA98925), M.A.Y. (R01 AI064590) and J.E.M. (F32 AI068366). E.V.R. gratefully acknowledges the Albert Billings Ruddock Professorship.
Funding AgencyGrant Number
NIHR01 CA90233
NIHR01 CA98925
NIHR01 AI064590
NIH Postdoctoral FellowshipF32 AI068366
Albert Billings Ruddock ProfessorshipUNSPECIFIED
Issue or Number:1
PubMed Central ID:PMC3131407
Record Number:CaltechAUTHORS:20150318-105708662
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:55889
Deposited By: Tony Diaz
Deposited On:18 Mar 2015 19:24
Last Modified:10 Nov 2021 20:51

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