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Reconstruction of genetic circuits

Sprinzak, David and Elowitz, Michael B. (2005) Reconstruction of genetic circuits. Nature, 438 (7067). pp. 443-448. ISSN 0028-0836. doi:10.1038/nature04335. https://resolver.caltech.edu/CaltechAUTHORS:20150325-092313161

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Abstract

The complex genetic circuits found in cells are ordinarily studied by analysis of genetic and biochemical perturbations. The inherent modularity of biological components like genes and proteins enables a complementary approach: one can construct and analyse synthetic genetic circuits based on their natural counterparts. Such synthetic circuits can be used as simple in vivo models to explore the relation between the structure and function of a genetic circuit. Here we describe recent progress in this area of synthetic biology, highlighting newly developed genetic components and biological lessons learned from this approach.


Item Type:Article
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http://dx.doi.org/10.1038/nature04335DOIArticle
http://rdcu.be/coJ5PublisherFree ReadCube access
ORCID:
AuthorORCID
Elowitz, Michael B.0000-0002-1221-0967
Additional Information:© 2015 Nature Publishing Group. 24 November 2005. Synthetic biology work in the laboratory is supported by a Burroughs-Wellcome CASI award, The HFSP program and the Searle Scholars program. D.S. would like to acknowledge the support of the Yad Hanadiv Foundation and the CBCD at Caltech. We would like to thank J. W. Chin, C. Guet, S. Leibler, J. Liao, W. Lim, C. Smolke and R. Weiss for contributing figures. We are grateful to R. Kishony, E. Sprinzak, C. Dalal, G. Suel and members of the laboratory for discussions and comments.
Issue or Number:7067
DOI:10.1038/nature04335
Record Number:CaltechAUTHORS:20150325-092313161
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150325-092313161
Official Citation:Sprinzak, D., & Elowitz, M. B. (2005). Reconstruction of genetic circuits. [10.1038/nature04335]. Nature, 438(7067), 443-448.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:56061
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:25 Mar 2015 16:52
Last Modified:10 Nov 2021 20:54

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