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The N-end rule and regulation of apoptosis

Varshavsky, Alexander (2003) The N-end rule and regulation of apoptosis. Nature Cell Biology, 5 (5). pp. 373-376. ISSN 1465-7392. doi:10.1038/ncb0503-373. https://resolver.caltech.edu/CaltechAUTHORS:20150325-153608289

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Abstract

The ubiquitin-dependent N-end rule pathway targets proteins for degradation through their destabilizing N-terminal residues. This pathway is known to control the import of peptides, chromosome stability and cardiovascular development. A new report identifies yet another function of the N-end rule pathway: the regulation of apoptosis through degradation of Drosophila melanogaster DIAP1.


Item Type:Article
Related URLs:
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http://dx.doi.org/10.1038/ncb0503-373 DOIArticle
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ORCID:
AuthorORCID
Varshavsky, Alexander0000-0002-4011-258X
Additional Information:© 2003 Nature Publishing Group.
Issue or Number:5
DOI:10.1038/ncb0503-373
Record Number:CaltechAUTHORS:20150325-153608289
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150325-153608289
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:56090
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:26 Mar 2015 02:37
Last Modified:10 Nov 2021 20:54

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