Khakh, Baljit S. and Zhou, Xiaoping and Sydes, Jason and Galligan, James J. and Lester, Henry A. (2000) State-dependent cross-inhibition between transmitter-gated cation channels. Nature, 406 (6794). pp. 405-410. ISSN 0028-0836. doi:10.1038/35019066. https://resolver.caltech.edu/CaltechAUTHORS:20150327-133158044
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Abstract
Transmitter-gated cation channels are detectors of excitatory chemical signals at synapses in the nervous system. Here we show that structurally distinct α3β4 nicotinic and P2X_2 channels influence each other when co-activated. The activation of one channel type affects distinct kinetic and conductance states of the other, and co-activation results in non-additive responses owing to inhibition of both channel types. State-dependent inhibition of nicotinic channels is revealed most clearly with mutant P2X_2 channels, and inhibition is decreased at lower densities of channel expression. In synaptically coupled myenteric neurons, nicotinic fast excitatory postsynaptic currents are occluded during activation of endogenously co-expressed P2X channels. Our data provide a molecular basis and a synaptic context for cross-inhibition between transmitter-gated channels.
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Additional Information: | © 2000 Macmillan Magazines Ltd. Received 12 April; accepted 26 May 2000. Thanks to H. Li for assistance with preparation of oocytes, and to other members of the group for comments. A Wellcome Trust (UK) International Prize Travelling Fellowship (to B.S.K.) and the NIH supported this work. | |||||||||
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Issue or Number: | 6794 | |||||||||
DOI: | 10.1038/35019066 | |||||||||
Record Number: | CaltechAUTHORS:20150327-133158044 | |||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20150327-133158044 | |||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
ID Code: | 56190 | |||||||||
Collection: | CaltechAUTHORS | |||||||||
Deposited By: | Tony Diaz | |||||||||
Deposited On: | 27 Mar 2015 21:30 | |||||||||
Last Modified: | 10 Nov 2021 20:55 |
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