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Diverse roles for ubiquitin-dependent proteolysis in transcriptional activation

Lipford, J. Russell and Deshaies, Raymond J. (2003) Diverse roles for ubiquitin-dependent proteolysis in transcriptional activation. Nature Cell Biology, 5 (10). pp. 845-850. ISSN 1465-7392. https://resolver.caltech.edu/CaltechAUTHORS:20150330-125857288

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Abstract

A growing literature points to a fundamental role for the ubiquitin–proteasome degradation system (UPS) in transcription. Four recent publications add significant insight to our understanding of the connections between these processes. Each provides evidence that some aspect of the UPS can stimulate the activity of transcriptional activators. UPS might promote transcription by several mechanisms, and in some cases, even the final step of the UPS — proteolysis — might enhance activator function.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1038/ncb1003-845DOIArticle
http://www.nature.com/ncb/journal/v5/n10/full/ncb1003-845.htmlPublisherArticle
http://rdcu.be/crw0PublisherFree Readcube access
ORCID:
AuthorORCID
Deshaies, Raymond J.0000-0002-3671-9354
Additional Information:© 2003 Nature Publishing Group.
Issue or Number:10
Record Number:CaltechAUTHORS:20150330-125857288
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150330-125857288
Official Citation:Lipford, J. R., & Deshaies, R. J. (2003). Diverse roles for ubiquitin-dependent proteolysis in transcriptional activation. [10.1038/ncb1003-845]. Nat Cell Biol, 5(10), 845-850.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:56217
Collection:CaltechAUTHORS
Deposited By: Joanne McCole
Deposited On:31 Mar 2015 18:56
Last Modified:03 Oct 2019 08:12

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