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Direct cortical input modulates plasticity and spiking in CA1 pyramidal neurons

Remondes, Miguel and Schuman, Erin M. (2002) Direct cortical input modulates plasticity and spiking in CA1 pyramidal neurons. Nature, 416 (6882). pp. 736-740. ISSN 0028-0836. doi:10.1038/416736a. https://resolver.caltech.edu/CaltechAUTHORS:20150331-101704328

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Abstract

The hippocampus is necessary for the acquisition and retrieval of declarative memories. The best-characterized sensory input to the hippocampus is the perforant path projection from layer II of entorhinal cortex (EC) to the dentate gyrus. Signals are then processed sequentially in the hippocampal CA fields before returning to the cortex via CA1 pyramidal neuron spikes. There is another EC input—the temporoammonic (TA) pathway—consisting of axons from layer III EC neurons that make synaptic contacts on the distal dendrites of CA1 neurons. Here we show that this pathway modulates both the plasticity and the output of the rat hippocampal formation. Bursts of TA activity can, depending on their timing, either increase or decrease the probability of Schaffer-collateral (SC)-evoked CA1 spikes. TA bursts can also significantly reduce the magnitude of synaptic potentiation at SC–CA1 synapses. The TA–CA1 synapse itself exhibits both long-term depression (LTD) and long-term potentiation (LTP). This capacity for bi-directional plasticity can, in turn, regulate the TA modulation of CA1 activity: LTP or LTD of the TA pathway either enhances or diminishes the gating of CA1 spikes and plasticity inhibition, respectively.


Item Type:Article
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http://dx.doi.org/10.1038/416736aDOIArticle
http://www.nature.com/nature/journal/v416/n6882/abs/416736a.htmlPublisherArticle
http://www.nature.com/nature/journal/v416/n6882/suppinfo/416736a.htmlRelated ItemSupplementary Information
http://rdcu.be/crraPublisherFree ReadCube access
ORCID:
AuthorORCID
Schuman, Erin M.0000-0002-7053-1005
Additional Information:© 2002 Macmillan Magazines Ltd. Received 26 December 2001; Accepted 28 January 2002. We thank G. Laurent for critial reading of the manuscript. This work was supported by Fundacao para a Ciencia e Tecnologia (FCT)—Portugal and the Howard Hughes Medical Institute.
Funders:
Funding AgencyGrant Number
Fundação para a Ciência e a Tecnologia (FCT)UNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Issue or Number:6882
DOI:10.1038/416736a
Record Number:CaltechAUTHORS:20150331-101704328
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150331-101704328
Official Citation:Direct cortical input modulates plasticity and spiking in CA1 pyramidal neurons p736 Miguel Remondes and Erin M. Schuman doi:10.1038/416736a
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:56241
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:31 Mar 2015 17:38
Last Modified:10 Nov 2021 20:56

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