Kitano, Hiroaki (2002) Computational systems biology. Nature, 420 (6912). pp. 206-210. ISSN 0028-0836. doi:10.1038/nature01254. https://resolver.caltech.edu/CaltechAUTHORS:20150331-151712115
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Abstract
To understand complex biological systems requires the integration of experimental and computational research — in other words a systems biology approach. Computational biology, through pragmatic modelling and theoretical exploration, provides a powerful foundation from which to address critical scientific questions head-on. The reviews in this Insight cover many different aspects of this energetic field, although all, in one way or another, illuminate the functioning of modular circuits, including their robustness, design and manipulation. Computational systems biology addresses questions fundamental to our understanding of life, yet progress here will lead to practical innovations in medicine, drug discovery and engineering.
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| Additional Information: | © 2002 Nature Publishing Group. I thank S. Imai, J. Doyle, J. Tyson, T.-M. Yi, N. Hiroi and M. Morohashi for their useful comments on the manuscript. This research is, in part, supported by: the Rice Genome and Simulation Project (Ministry of Agriculture), International Standard Development area of International Joint Research Grant (New Energy and Industrial Technology Development Organization (NEDO)/Japanese Ministry of Economy, Trade and Industry (METI)), Exploratory Research for Advanced Technology (ERATO) and Institute for Bioinformatics Research and Development (BIRD) program (Japan Science and Technology Corporation), and through the special coordination funds for promoting science and technology from the Japanese government’s Ministry of Education, Culture, Sports, Science, and Technology. | ||||||||||||||||
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| Issue or Number: | 6912 | ||||||||||||||||
| DOI: | 10.1038/nature01254 | ||||||||||||||||
| Record Number: | CaltechAUTHORS:20150331-151712115 | ||||||||||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20150331-151712115 | ||||||||||||||||
| Official Citation: | Computational systems biology p206 Hiroaki Kitano doi:10.1038/nature01254 | ||||||||||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||||||
| ID Code: | 56259 | ||||||||||||||||
| Collection: | CaltechAUTHORS | ||||||||||||||||
| Deposited By: | Ruth Sustaita | ||||||||||||||||
| Deposited On: | 31 Mar 2015 22:58 | ||||||||||||||||
| Last Modified: | 10 Nov 2021 20:57 |
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