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Repression of AGAMOUS-LIKE 24 is a crucial step in promoting flower development

Yu, Hao and Ito, Toshiro and Wellmer, Frank and Meyerowitz, Elliot M. (2004) Repression of AGAMOUS-LIKE 24 is a crucial step in promoting flower development. Nature Genetics, 36 (2). pp. 157-161. ISSN 1061-4036. doi:10.1038/ng1286. https://resolver.caltech.edu/CaltechAUTHORS:20150408-084519948

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Abstract

Flower development begins as floral meristems arise in succession on the flank of the inflorescence meristem. Floral meristem identity genes LEAFY (LFY) and APETALA1 (AP1) promote establishment and maintenance of floral identity in newly formed floral primordia. Without their activity, the floral primordia develop with inflorescence characteristics. The underlying molecular-genetic mechanism is unknown. Here we show that these phenotypes are due in large part to the ectopic expression of AGAMOUS-LIKE 24 (AGL24), a central regulator of floral meristem identity. We present evidence that AGL24 is an early target of transcriptional repression by LFY and AP1. Without such repression, continued AGL24 expression in floral meristems is sufficient to cause floral reversion regardless of the activation of floral organ identity genes. This indicates that LFY and AP1 promote floral development not only by positively regulating genes activated in flower development, but also by repressing AGL24, a promoter of inflorescence fate.


Item Type:Article
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URLURL TypeDescription
http://dx.doi.org/10.1038/ng1286DOIArticle
http://www.nature.com/ng/journal/v36/n2/abs/ng1286.htmlPublisherArticle
http://www.nature.com/ng/journal/v36/n2/suppinfo/ng1286_S1.htmlPublisherSupplementary Information
ORCID:
AuthorORCID
Ito, Toshiro0000-0002-8206-2787
Meyerowitz, Elliot M.0000-0003-4798-5153
Additional Information:© 2004 Nature Publishing Group. Received 3 November; accepted 2 December 2003. Published online: 11 January 2004. We thank P.P. Kumar and members of the laboratory of E.M.M. for comments. This work was supported by a grant from the US National Institutes of Health (to E.M.M.). H.Y. was supported by an overseas postdoctoral fellowship from National University of Singapore and a grant from the US National Institutes of Health (to E.M.M.).
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Funding AgencyGrant Number
NIHUNSPECIFIED
National University of SingaporeUNSPECIFIED
Issue or Number:2
DOI:10.1038/ng1286
Record Number:CaltechAUTHORS:20150408-084519948
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150408-084519948
Official Citation:Repression of AGAMOUS-LIKE 24 is a crucial step in promoting flower development Hao Yu, Toshiro Ito, Frank Wellmer & Elliot M Meyerowitz Nature Genetics 36, 157 - 161 (2004) Published online: 11 January 2004; | doi:10.1038/ng1286
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:56466
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:08 Apr 2015 19:37
Last Modified:10 Nov 2021 20:59

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