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Temporal structure in neuronal activity during working memory in macaque parietal cortex

Pesaran, Bijan and Pezaris, John S. and Sahani, Maneesh and Mitra, Partha P. and Andersen, Richard A. (2002) Temporal structure in neuronal activity during working memory in macaque parietal cortex. Nature Neuroscience, 5 (8). pp. 805-811. ISSN 1097-6256. https://resolver.caltech.edu/CaltechAUTHORS:20150408-095310392

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Abstract

Many cortical structures have elevated firing rates during working memory, but it is not known how the activity is maintained. To investigate whether reverberating activity is important, we studied the temporal structure of local field potential (LFP) activity and spiking from area LIP in two awake macaques during a memory-saccade task. Using spectral analysis, we found spatially tuned elevated power in the gamma band (25−90 Hz) in LFP and spiking activity during the memory period. Spiking and LFP activity were also coherent in the gamma band but not at lower frequencies. Finally, we decoded LFP activity on a single-trial basis and found that LFP activity in parietal cortex discriminated between preferred and anti-preferred direction with approximately the same accuracy as the spike rate and predicted the time of a planned movement with better accuracy than the spike rate. This finding could accelerate the development of a cortical neural prosthesis.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1038/nn890 DOIArticle
http://www.nature.com/neuro/journal/v5/n8/full/nn890.htmlPublisherArticle
http://www.nature.com/neuro/journal/v5/n8/suppinfo/nn890_S1.htmlPublisherSupplementary Methods
ORCID:
AuthorORCID
Andersen, Richard A.0000-0002-7947-0472
Additional Information:© 2002 Nature Publishing Group. Received 25 January 2002; Accepted 26 June 2002; Published online: 22 July 2002. This work was supported by the DARPA grant MDA972-00-1-0029, NIH grants EY05522-21 and MH62528-01, ONR grant N00014-94-0412, the Keck Foundation, the McKnight Foundation, the Sloan-Swartz Foundation, the Center for Neuromorphic Systems Engineering at Caltech and the Workshop for the Analysis of Neural Data (http://www.vis.caltech.edu/~WAND).
Funders:
Funding AgencyGrant Number
Defense Advanced Research Projects Agency (DARPA)MDA972-00-1-0029
NIHEY05522-21
NIHMH62528-01
Office of Naval Research (ONR)N00014-94-0412
W. M. Keck FoundationUNSPECIFIED
McKnight FoundationUNSPECIFIED
Sloan-Swartz FoundationUNSPECIFIED
Caltech Center for Neuromorphic Systems EngineeringUNSPECIFIED
Workshop for the Analysis of Neural DataUNSPECIFIED
Issue or Number:8
Record Number:CaltechAUTHORS:20150408-095310392
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150408-095310392
Official Citation:Pesaran, B., Pezaris, J. S., Sahani, M., Mitra, P. P., & Andersen, R. A. (2002). Temporal structure in neuronal activity during working memory in macaque parietal cortex. [10.1038/nn890]. Nat Neurosci, 5(8), 805-811.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:56469
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:08 Apr 2015 22:23
Last Modified:09 Mar 2020 13:18

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